Endocrine Abstracts

JOINT897

Background: Type 1 diabetes (T1D) is a chronic autoimmune disorder that requires ongoing management of blood glucose levels to prevent long-term complications. Recent studies have suggested a potential link between vitamin D status and glycemic control in individuals with diabetes.

Purpuse: The aim was to study the relationship between 25-hydroxy vitamin D (25(OH)D) levels and glycemic control in patients with type 1 diabetes.

Methods: We conducted a cross-sectional study, including 50 type 1 diabetic patients. All participants underwent a thorough assessment, including the measurement of 25-hydroxyvitamin D, as well as the assessment of fasting blood glucose and hemoglobin A1c levels.

Results: The median age of the participants was 26 years [21.00 - 31.75], with a sex ratio (F/M) of 1.4. The median duration of diabetes was 13.00 years [9.25 - 17.75]. The average level of 25(OH)D was 11.14 ± 6.49 and 56% of patients had a severe deficiency (≤10 ng/ml). The assessment of glycemic control showed that 78% of patients had a fasting blood glucose level above the therapeutic target (7.2 mmol/l), and 66% had an HbA1c ≥ 9%. The analysis of the association between glycemic control and 25(OH)D levels revealed that patients with elevated fasting blood glucose levels had a lower median 25(OH)D level compared to those with fasting blood glucose within therapeutic targets but without a statistically significant difference (8.93 ng/ml [7.57 – 13.89] versus 11.42 ng/ml [6.88 – 15.42]; P = 0.61). Furthermore, patients with an HbA1c ≥ 9% had a lower median 25(OH)D level compared to those with an HbA1c < 9% (11.39 ng/ml [8.44 – 14.44] versus 8.74 ng/ml [7.08 – 13.25]; P = 0.14).

Conclusion: Although patients with elevated blood glucose levels tended to have lower median 25(OH)D levels compared to those with glycemic control within target ranges, these differences were not statistically significant. Further research with larger sample sizes may be needed to better understand the relationship between vitamin D levels and glycemic control in type 1 diabetic patients.