ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Screening for celiac disease in children with type 1 diabetes, is it necessary? twenty-five years of experience in a single center
Roland Schweizer 1 , Julia Bung 1 , David Majer 1 , Franziska Liebrich 1 , Susann Herrlich 1 , Andreas Neu 1 & Julian Ziegler 1
1Pediatric Diabetology, University Children’s Hospital, Tübingen, Germany
JOINT2876
Patients with type 1 diabetes (T1D) have an increased risk of developing additional autoimmune diseases. The risk of developing celiac disease (CD) is 3-4 times higher in children with T1D. Guidelines recommend regular screening for transglutaminase antibodies (TgAb) in T1D children. CD could be an additional burden for T1D children as both diseases affect food intake. We describe the screening practice for CD during the last 25 years in our outpatient clinic in children with T1D. Methods: We retrospectively analysed the development of CD-specific antibodies in our patients with T1D (diabetes onset since 1998). We did not always recommend endoscopy when CD-specific antibodies (TgAb, endomysium (EAb), gliadin) were positive and patients had no CD-specific symptoms. Results: We analysed 304 patients. 122 had CD-specific antibodies. In 98 of them, they disappeared after a short time or were only slightly elevated. The diagnosis of CD was confirmed in 12. All 12 showed CD-specific symptoms such as failure to thrive, anaemia, hypoglycaemia or gastrointestinal problems. In 6 patients, even severely elevated EAb and/or TgAb disappeared on average after 7.1 years (range 4.9 to 13.5 years) on gluten-containing diet. The remaining 6 had antibodies without CD-specific symptoms by the end of the observation period. The time with antibody-positivity was 4 years (range 1.8 to 11.6 years).
Conclusion: We conclude that even highly elevated CD-specific antibodies can disappear in children with T1D and therefore screening for CD-specific antibodies is only useful in symptomatic children with T1D.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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