Endocrine Abstracts

JOINT2448

Background: Oral glucose tolerance test (OGTT) is used for diagnosis of diabetes and insulin resistance. There are different modifications of OGTT with measurement of glucose and insulin level on 0, 30, 60, 120 and additional minutes. But weather OGTT is presenting information for treatment effect.The aim of our study is to assess the importance of measurement of insulin secretion during oral glucose tolerance test for predicting obesity treatment success.

Materials and methods: Our survey include 109 patients (59 women, 50 men, mean age 40.01±11.80years). Patients were divided into three groups and were assigned to treatment with diet, metformin or GLP-1 agonist. All patients underwent OGTT with measurement of glucose and insulin, which was performed on minute 0, 60 and 120. The groups did not differ by gender, weight, BMI or age. Assessment of weight and BMI was done in six months period. The treatment effect was defined as more than 10% weight loss.

Results: Satisfactory treatment results were found in patients with increased insulin level at 0 min (15.2±3.5 vs 11.3±3.1mU/l, P<0.05) and 60 min (145.2±26.5 vs 87.3±25.1mU/l, P<0.05). There was no difference between insulin levels on 120 min in responders and non-responders (45.2±12.5 vs 39.3±9.1mU/l, P>0.05). Insulin levels of 0 and 60 min demonstrated moderate positive correlation with percentage of weight loss (r=0.564) in group only on diet or metformin, but not in GLP1 agonist treated group.

Conclusion: Measurement of insulin level during OGTT presents information about insulin secretion curve and could be used for prediction of treatment effect in obese patients receiving only diet or metformin, but not in GLP1 agonist treated patients