Endocrine Abstracts

JOINT2566

Introduction: Home parenteral nutrition (HPN) is the nutrition access of choice in patients with documented intestinal failure and inability to receive enteral nutrition exclusively.

Material and Objective: Retrospective descriptive study of patients who received HPN during 2023. Demographic variables related to HPN administration and nutritional status were analysed. The objective was to analyse the experience in the use of HPN and possible complications arising from the infusion in the Hospital Reina Sofia of Cordoba.

Results: 11 patients. 9/11 women. Median age 61 years (30-87). Median follow-up time with HPN was 34 months (SDS 26.7). 8 patients with indication for HPN due to short bowel syndrome (SBS), 2 due to intestinal fistula, 1 due to extensive intestinal mucosal disease. The cause of SBS was mesenteric ischaemia (1), Crohn’s disease (2), surgical complications (3), intestinal volvulopathy (1), adhesive syndrome (1). 72.7% (8) had an ostomy. Initially, 9/11 patients had PICC and 2/11 had Hickman as a central access route. At the end of follow-up, 100% of patients had PICC. According to the severity classification of chronic intestinal failure in adults: 3 FE1, 1 FE2, 3 PN1, 4 PN2. Mean kcal provided by HPN 1264 ± 155Kcal. 1 patient receiving Teduglutide treatment for 13 months. 4/11 patients had infectious catheter-related complications. 4/11 patients had catheter-related mechanical complications, mostly associated with catheter obstruction. 2/11 patients had their HPN withdrawn after 43 months (mean) of treatment, due to cure or improvement of their disease and nutritional parameters. 1 patient died due to catheter-associated complications. Weight prior to initiation of HPN 49.8 ± 11.4 kg, weight at last HPN follow-up 58.24 ± 13.6 kg [t -2.187, P =0.071]. BMI prior to initiation of HPN 19.8 ± 4.76 kg/m². BMI at last HPN visit 24.6 ± 7.8 kg/m² [t -2.01, P =0.071]. There is a trend towards improvement in albumin, pre-albumin, transferrin, total cholesterol, triglycerides, lymphocytes and haemoglobin after HPN, although the differences are not statistically significant.

Conclusions: The age and indication for HPN in our series is similar to the literature. There was an improvement in the weight and BMI of the patients after HPN and we did not find statistically significant differences in the improvement of nutritional parameters, although there was a trend towards improvement.