ECEESPE2025 ePoster Presentations Reproductive and Developmental Endocrinology (128 abstracts)
Sociodemographic and metabolic profiling of transgender and gender diverse treatment-naïve adolescents – seven-year experience in the first gender unit dedicated to youth in poland
Wiktoria Kempińska 1,2 , Aleksandra Januszek-Trzciąkowska 1,2 , Dorota Karbowska 1,2 , Aleksandra Antosz 1,2 , Kamila Szeliga 1,2 , Zuzanna Gawlik 3 , Tomasz Jakubowski 2,4 , Agnieszka Bielska-Brodziak 5 & Aneta Gawlik-Starzyk 1,2
1Faculty of Medical Sciences, Medical University of Silesia, Department of Pediatrics and Pediatric Endocrinology, Katowice, Poland; 2Upper Silesian Child Health Center, Public Clinical Hospital No. 6 of the Silesian Medical University, Institute of Psychology, University of Silesia, Katowice, Poland; 3Pediatric Institute - Medical College, Jagiellonian University in Cracow, Department of Pediatric and Adolescent Endocrinology, Cracow, Poland; 4Institute of Psychology, University of Silesia, Katowice, Poland; 5Faculty of Law and Administration, University of Silesia, Katowice, Poland
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Introduction: The rise in referrals of transgender and gender diverse children and adolescents to clinical diagnosis is a widely discussed topic around the word. Similarly to adult population they are at risk for weight-related problems resulting from pathological eating behaviors, which in turn negatively influence the individual’s metabolic health.
Aim: We assess the basic sociodemographic and metabolic profile of the youth population in the first clinical unit dedicated to transgender youth in our country.
Methods: This prospective study has examined a consecutive series of transgender and gender diverse children and adolescents (TGDC&A) based on WPATH SOC-8 between July/2017 and Sep/2024. Clinical and laboratory data was collected in unified medical records. Sociodemographic and TGDC&A history has been analysed alongside anthropometric and metabolic parameters. The population has been divided into registered female (RFAB) or male at birth (RMAB) groups.
Results: The population consists of 269 participants (230 RFAB, 39 RMAB), with increasing number of diagnosis in subsequent years 2017 (July-Dec) - 2/0, 2018 - 9/0 2019-16/3, 2020-18/4, 2021- 52/3, 2022- 68/22, 2023- 51/4, 2024 (Jan-Sep) 14/3 (RFAB/RMAB, respectively), with the mean/median age of diagnosis 15.8/16.1 years and the mean age of gender identity mismatch onset of 12 years. BMI distribution, fasting components of the metabolic syndrome and cortisol in circadian rhythm are presented in table.
| Variables | all (n = 269) | RFAB (n = 230) | RMAB (n = 39) | |
| BMI (centiles) | >97[n/%] | 61/22.7 | 56/24.3 | 5/12.8 |
| 90-97 [n/%] | 33/12.3 | 29/12.6 | 4/10.3 | |
| 10-90[n/%] | 150/55.8 | 126/54.8 | 24/61.5 | |
| 3-10 | 15/5.6 | 13/5.7 | 2/5.1 | |
| <3 | 10/3.7 | 6/2.6 | 4/10.3 | |
| z-score BMI (IOTF) [median, mean+/-SD] | 0.660.72+/-1.2 | 0.74 0.79+/-1.2 | 0.27 0.35+/-1.3 | |
| Fasting blood | glucose = or >100 mg/dl | 16/5.9 | 14/6.1 | 2/5.1 |
| HOMA-IR >2.5 | 94/34.9 | 80/34.8 | 14/35.9 | |
| triglycerides >150 mg/dl | 20/7.4 | 20/8.7 | 0/0.0 | |
| HDL-cholesterol <40 mg/dl | 26/9.7 | 18/7.8 | 8/20.5 | |
| morning cortisol > 25mg/dl | 4/1.5 | 4/1.7 | 0/0.0 | |
| midnight cortisol >5.7mg/dl | 17/6.3 | 15/6.5 | 2/5.1 |
Conclusions: Sociodemographic fluctuations in the proportion of RFAB/RMAB are visible, however difficult to explain now. The increased risk of abnormal BMI, mostly elevated in RFAB and decreased in RMAB, and higher risk of metabolic syndrome/complications are key issues to consider when preparing patients with GI/GD for medical transition.
Volume 110
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Endocrine Abstracts
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