ECEESPE2025 ePoster Presentations Thyroid (198 abstracts)
Dozens of doubts: a series of atypical presentations of medullary thyroid carcinoma running title: atypical presentations of medullary thyroid carcinoma
Sanja Medenica 1 , Ananda Mohan Chakraborty 2 , Ana Ostojic 3 , Liza Das 2 , Uma Nahar Saikia 4 , Rajender Kumar 5 , Debajyoti Chatterjee 4 & Pinaki Dutta 2
1University of Montenegro, Department of Endocrinology, Podgorica, Montenegro; 2PGIMER, Chandigarh, Department of Endocrinology, Chandigarh, India; 3University of Montenegro, Department of Pulmonary Medicine, Podgorica, Montenegro; 4PGIMER, Chandigarh, Department of Histopathology, Chandigarh, India; 5PGIMER, Chandigarh, Department of Nuclear Medicine, Chandigarh, India.
JOINT2726
Medullary thyroid carcinoma (MTC), originating from parafollicular C cells, accounts for 5- 10% of thyroid malignancies but is responsible for 15% of thyroid cancer-related mortality. This case series reviews 12 atypical presentations of MTC, highlighting significant diagnostic and therapeutic challenges. About 80% of MTC cases are sporadic, while 20% are hereditary, often linked to multiple endocrine neoplasia (MEN) syndromes. The predominant clinical manifestations include neck swelling, diarrhoea, and metastatic symptoms. In our cohort of 80 MTC patients, we identified 5 with considerable diagnostic ambiguity and with management complexities due to therapy-related complications. Notably, we observed cases with coexisting conditions such as chondrosarcoma, concurrent carcinoma prostrate, and ectopic Cushing’s syndrome, complicating the clinical picture. We also had one female subject who have presented at the age of 16 years with negative RET mutation. One patient demonstrated a rare association with Marfanoid habitus linked to a RET mutation. One of them presented with metachronous VHL spectrum (Pheochromocytoma, pancreatic cysts and clear cell subtype of renal cell carcinoma) disease with MTC. one each presented with bowel perforation in an area uninvolved by metastatic process attributed to Lenvatinib treatment and glomerulonephritis due to tyrosine kinase inhibitor. This series underscores the necessity for comprehensive evaluation and individualized management strategies in MTC cases. Cases and figures will be elaborated during presentation. Given the potential for diverse clinical presentations and complications, our cases highlight the importance of awareness among healthcare providers regarding the varied manifestations of MTC, which can obscure diagnosis and complicate treatment.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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