Endocrine Abstracts

JOINT2129

Background: Sarcopenia is proposed as a complication of type 1 diabetes (T1D1). However, there are few studies on its prevalence and related clinical outcomes in TD1. Our aim was to analyze whether sarcopenia and dynapenia are more common in people with TD1, as well as to determine if there are associations with disease-related factors.

Methods: A cross-sectional study of young subjects with DT1 and healthy controls matched for age, sex and body mass index (BMI). The following variables were collected: DT1-related clinical and metabolic data, muscle strength measured with the Jamar dynamometer and quadriceps rectus femoris muscle mass (Y-axis, X-axis, area and circumference) measured with ultrasound. The appendicular skeletal mass index (ASMI) was assessed by calf circumference to define myopenia. Regarding dynapenia, a cut-off point at p10 was used according to the Spanish population percentile table. Statistical analysis was performed with IBM SPSS v.25.

Results: 34 patients with DT1 (40 ± 14 years; 54.4 % female and BMI 24.4± 4.09 kg/m²) were analyzed. In the case group, the mean HbA1c was 6.85 ± 1.84%, the frequency of microvascular complications was 32.4% (8.8% presented nephropathy, 23.5% retinopathy, 17.6% polyneuropathy). There were no patients with macrovascular complications. Regarding the strength measured by dynamometry was 31.2 ± 10.9 kg in cases vs. 34.2 ± 12.9 kg in controls (P= 0.313). Calf circumference values were significantly lower in the DT1 group (35.2 ± 2.7 cm vs. 37.8 ± 2.9 cm; P = 0.00). The ASMI value was 6.57 ± 1.21 kg/m² in cases and 7.25 ± 1.31 kg/m² in controls (P = 0.31). Patients with myopenia accounted for 29.4% of cases and 12.1% of controls (P = 0.082). The prevalence of dinapenia did not show statistically significant differences between groups (26.5% in cases vs. 18.8% in controls; P = 0.454). Finally, sarcopenia was observed in 2 cases and 1 control (5.9% vs. 2.9% respectively; P = 0.55).

Conclusions: Deterioration of muscle strength in DT1 and muscle mass was observed. However, the prevalence of dynapenia and sarcopenia was not significantly higher in DT1, at least, in this young population. Further studies are needed in this and other groups with larger sample to confirm these results.