ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
The importance of interleukin 6 in the detection of silent myocardial ischemia in patients with tipe 2 diabetes
Gabrijela Malesevic 1 , Snjezana Popovic Pejicic 1 , Valentina Soldat Stankovic 1 , Tamara Kovacevic Preradovic 1 , Bojan Stanetic 1 , Ljiljana Kos 1 , Bojana Caric 1 & Ivona Risovic 1
1University Clinical Centre of the Republic of Srpska, Medical Faculty, University of Banja Luka, Bosnia and Herzegovina, Department of Endocrinology, Banja Luka, Bosnia and Herzegovina
JOINT2586
Introduction and aim: A special feature of Coronary Heart Disease (CHD) in patients with type 2 diabetes (T2D) is that it is often asymptomatic and occurs as a consecuence of cardiovascular auotonomic neuropathy. Predicting the risk of cardiovascular events occurrence and progression of atherosclerosis and correlation of inflammatory agents in its progression has increasingly been the focus of research. Increased levels of interleukin 6 (IL-6) accelerates atherosclerosis and occurrence of cardiovascular complications in patients with T2D. Therefore, the determination of IL 6 in these patients would be significant in stratifying the risk of CHD. The aim of the study was to evaluate the importance of determining inflammatory cardiovascular risk markers IL-6 in screening for the presence of CHD in asymptomatic patients with T2D.
Methods: The cross-sectional study included 159 patients with T2D, without any symptoms and signs of CHD and no previous history CHD. Ergometric testing proved or ruled out the presence of silent CHD. The levels of IL-6 were determined by ELISA.
Results: IL6 values were significantly higher in patients with positive ergometric test (5.83±1.99 pg/mL) compared to patients with negative ergometric test (2.04±1.39 pg/mL) (P<0.001). The patients with higher IL-6 values were 1.457 more likely to have positive ergometric tests than those with lower IL-6 (P<0.05). The combination of IL-6, glycoregulation parameters (HbA1c) and duration of diabetes are significant predictors of silent ischemia. With their increase, the probability of a positive ergometric test also increases (P<0.01).
Conclusion: It was proven that there was a greater possibility of the presence of silent CHD in asymptomatic patients with T2D with higher values IL-6 and their determination could be recommended in improving cardiovascular risk stratification in asymptomatic patients with T2D.
Key words: diabetes mellitus, coronary heart disease, interleukin 6.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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