Endocrine Abstracts

JOINT482

Metabolic syndrome (MS) is cluster of risk factors for cardiovascular diseases. None of the available versions of recommendations for the diagnosis of MS hyperuricemia (HU) is not recognized as a criterion of MS, although some MS and HU are quite common.The aim Analysis of the relationship of HU with the components of the MS in a random population sample.

Materials and Methods: The group of subjects (n =727) was formed according to the generally accepted epidemiological approaches by the method of random sampling from among the workers and employees of the industrial enterprise (average age (38.13±5.1) years). Statistical processing of the results was performed using Package for Social Sciences v.16.0 (SPSS Inc, Chicago, Il, USA).

Results And Discussion.: HU was diagnosed in 16.2% of people. It has been established that in people with HU the probability of diagnosis of impaired of glucose homeostasis (IGH) increases by 5.1 times, type 2 DM by 3.7 times, obesity by 2.9 times, arterial hepertension (AG) by 2.3 times and dyslipidemia by 1.7 times, respectively. It is determined that almost every second case of HU in a random population sample is associated with at least two more components of MS (AG + obesity), in every fourth case – with three components (AG + obesity + dyslipidemia), in every eighth case – with four components (AG + obesity + dyslipidemia + IGH). It was found that in every fourth representative of the random population sample, who was diagnosed with impaired of glucose tolerance and type 2 DM, has a "complete" MS; the probability of diagnosing MS in people with IGH increases 10 times compared with the population.

Conclusions: If the verification of "complete" MS is not limited to the mandatory inclusion of HU, the frequency of diagnosis in one member of a random population sample of the quartet of symptoms (obesity + AG + dyslipidemia + hyperinsulinemia) doubles and is already 4.0% of the total random population sample. Under this condition, every second representative of the random population sample of IGH is diagnosed with "complete" MS.

Keywords: hyperuricemia, metabolic syndrome, impaired of glucose homeostasis, impaired glucose tolerance, type 2 diabetes mellitus.