Endocrine Abstracts

JOINT2022

Background: The relationship between Type 2 Diabetes Mellitus(T2DM) and Chronic Obstructive Pulmonary Disease (COPD) is known to be bidirectional. Diabetes Mellitus (DM) and hyperglycemia are important risk factors for poor outcomes in hospitalized patients with acute exacerbation of COPD (AECOPD). There is limited data regarding specific outcomes in diabetic patients with AECOPD and still many issues need to be clarified about the impact of T2DM in this patient population.

Objective: This study aimed to evaluate the impact of previously known and newly diagnosed DM, on outcomes of hospitalised patients with AECOPD.

Methods: A total of 100 hospitalized patients diagnosed with AECOPD, during the interval January-March 2024, in e tertiary Hospital Center in Albania, were included in the present study. Outcomes of diabetic- AECOPD patients were compared with non-diabetic AECOPD patients. Markers associated with development of type 2 DM were identified. At the same time we analysed how glycemic control during the hospitalization period could influence final outcomes regarding in-hospital case fatality and in-hospital adverse events.

Results: Of the 100 patients enrolled in this study, the overall prevalence of T2DM was 31%, with average glucose values X = 245 mg/dl (min 93mg/dl —max 556 mg/dl). The T2DM group had higher inflammatory marker levels and a longer hospital stay versus the non-diabetic group. Age, increased inflammatory markers, elevated blood glucose on admission and inhospital were all risk factors for complications like need for assisted ventilation and mortality in hospitalized AECOPD patients.

Conclusions: AECOPD patients had a higher prevalence of T2DM than the general population; T2DM comorbidity caused longer hospital stays, and increased risc of inhospital complications in AECOPD hospitalised patients. Poor blood glucose control may increase the risk of mortality in AECOPD patients.

Keywords: Type 2 diabetes mellitus, COPD, Acute exacerbation of COPD, Glycemic control, Outcomes.