ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Kaposi sarcoma manifesting as leg lesions in a patient with diabetes mellitus: a case report
Nada Hassairi 1 , Kouloud Boujelben 1 , Mouna Elleuch 1 , Yesmine Elloumi 1 , Mouna Mnif 1 , Nadia Charfi 1 , Faten Haj Kacem Akid 1 , Mohamed Abid 1 , Dhoha Ben Salah 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT2485
Introduction: Kaposi’s sarcoma can be defined as a mesenchymal proliferative process involving cells of the blood and lymphatic system, caused by human herpes virus type 8. Diabetic patients are generally prone to pathogenic infections and tumor involvement.
Case Report: Herein, we report the case of Kaposi sarcoma in a Tunisian 52-year-old female with type 2 diabetes progressing for 10 years and managed with insulin therapy, at the stage of chronic macroangiopathic and microangiopathic complications. The current history dates back a few months, when the patient presented to our department with multiple raised violaceous flat patches located on both lower legs. Deep and superficial sensations were preserved and pulses were palpable. The X-ray of legs was unremarkable. A skin biopsy was performed and the immunohistochemical study had shown tumor cells expressing human herpes virus type 8 and CD34. Kaposi’s sarcoma associated virus was retained. The etiological investigation of an associated opportunistic infection was negative. There was no evidence of internal organ involvement on whole –body CT scan. Then, the patient underwent treatment with topical alitretinoin 0.1% gel by dermatology. Lesions were remarkably ameliorated. Adjuvant radiotherapy was proposed but refused by the patient.
Conclusion: Our case illustrates the potential association between diabetes and Kaposi’s sarcoma and emphasizes the importance of clinical examination in the detection of tumor lesions in diabetics. Rigidly control glucose levels were required allowing for long-term remission and reduction of complications.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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