ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Co-occurrence of Ketoacidosis Decompensation and Acute Pancreatitis in Type 1 Diabetic Patients: Clinical and Biological Specificities
Dhoha Ben Salah 1 , Nada Hassairi 1 , Kouloud Boujelben 1 , Oumaima Dimassi 1 , Faten Haj Kacem Akid 1 , Nadia Charfi 1 , Mouna Mnif 1 , Mohamed Abid 1 , Mouna Elleuch 1 & Nabila Rekik Majdoub 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT2687
Objective: To describe the clinical and biological presentation characterizing the simultaneous occurrence of acute pancreatitis (AP) and diabetic ketoacidosis (DKA) in type 1 diabetes (T1D).
Patients and Methods: A retrospective descriptive study including 10 T1D patients who presented with a simultaneous episode of DKA and AP.
Results: The average age at T1D diagnosis was 19.7±9.3 years, with a female predominance (60%). T1D was frequently first diagnosed through classic cardinal symptoms (50%) or spontaneous DKA (20%). In 10% of cases, T1D was diagnosed during an AP episode, classified as stage E in 57.1% of cases. The mixed AP-DKA episode occurred at an average age of 26.9±14.9 years. A febrile presentation was frequently reported (30%), along with general state impairment (20%) and severe dehydration (10%). Respiratory and neurological symptoms were present in 20% of cases. Gastrointestinal symptoms were pronounced, particularly epigastric pain (90%), vomiting (50%), and diarrhea (20%). Urinary ketones were markedly elevated in 50% of cases, with an average blood glucose level of 3.2±1.4 g/l. Metabolic acidosis was present in all cases, with mean pH and bicarbonate values of 7±0.3 and 12.3±8.3, respectively. Functional renal failure complicated 10% of cases. An infectious syndrome was observed in 40% of cases, with an average CRP level of 47±72.9 mg/l. All patients showed favorable outcomes after appropriate resuscitation, with insulin requirements estimated at 0.76±0.3 IU/kg/day.
Discussion: The co-occurrence of DKA and AP in T1D is a relatively rare but potentially severe event due to the reciprocal deleterious effects of both conditions. The prognosis of this mixed emergency depends on early diagnosis and prompt resuscitation.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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