Asymptomatic hyperuricemia: prevalence and risks

Siwar Saoudi; Ramla Mizouri; Othman Rym Ben; Hadhemi Belhassen; Faten Mahjoub; Berriche Olfa; Amor Nadia Ben; Jamoussi Henda

doi:10.1530/endoabs.110.EP467

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Endocrine Abstracts (2025) 110 EP467 | DOI: 10.1530/endoabs.110.EP467

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Asymptomatic hyperuricemia: prevalence and risks

Siwar Saoudi ¹ , Ramla Mizouri ¹ , Rym Ben Othman ¹ , Hadhemi Belhassen ¹ , Faten Mahjoub ¹ , Berriche Olfa ¹ , Nadia Ben Amor ¹ & Jamoussi Henda ¹

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¹Institute of Nutrition of Tunis, Tunis, Tunisia

JOINT3524

Introduction: Hyperuricemia is a disease, that excess uric acid can lead to precipitation of uric acid into urate crystals. Asymptomatic hyperuricemia is defined as a biological abnormality characterized by elevated blood uric acid levels with no clinical manifestations.

Methods: It was a descriptive cross sectional study conducted in department A of the institute of Nutrition of Tunis which included patients with type 2 diabetes. Hyperuricemia was defined by a uric acid level that exceed 360mg/l.

Results: The total number of patients who participated in the study was 120. The characteristics of the patients were respectively: age 47±9 years, Body mass index (BMI) 29 ± 4.2 Kg/m², HbA1c 10.8 ±2.4%. The mean duration of diabetic patients was 11±7years. Hyperuricemia was present in 34.8%, with a mean level of 411 ± 19.6 mg/l. Twenty two percent have asymptomatic hyperuricemia: 78% of patients have arterial hypertension, 64.1% with microangiopatic complications, 21% with a history of stroke, 22.5% with coronary disease, 67% with arteriopathy. As for the metabolic profile of patients with asymptomatic hyperuricemia, 98% with low HDLc, high LDLc in 79.7%, high triglycerides in 66.4 %. Asymtomatic hyperuricemia was positively correlated with BMI(p =0.001) and duration of diabetes (p = 0.009) and it was significantly more frequent with coronary disease (p= 0.01) and with dyslipidemic patients (p =0.007).

Conclusion: Asymptomatic hyperuricemia is common in our population. It is equivalent to symptomatic hyperuricemia in terms of complications and aggravation of comorbidity. It was positively correlated with BMI, duration of diabetes, coronary disease and dyslipidemia.