ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Association of type 1 diabetes and celiac disease
Siwar Saoudi 1 , Olfa Lajili 1 , Chaima Jemai 1,2 , Hadhemi Belhassen 1 , Zohra Hadj Ali 1 , Hedfi Imene 1 , Yosra Htira 1 & Feika Ben Mami 1
1Institute of Nutrition of Tunis, Tunis, Tunisia; 2Institute of Nutrition, Tunis, Tunisia
JOINT3553
Objective: Type 1 diabetes (T1DM) and celiac disease (CD) are autoimmune inflammatory diseases caused by the interaction of genetic and environmental factors. The aim of this study was to determine the prevalence and characteristics of CD in type 1 diabetic patients.
Methods: We conducted a cross-sectional study of 80 type 1 diabetic patients followed up in ward C of the Tunis Institute of Nutrition. Patients were divided into two groups: Group 1 (G1):40 T1DM patients with negative CD serology and Group 2 (G2): 40 type 1 diabetics with positive CD serology.
Results: The mean age of our population was 28±8 years. The mean duration of diabetes was 9±5.6 years. Among G2 patients, 13 had positive Ig A anti-transglutaminase autoantibodies and 30 patients underwent jejunal biopsy with histological confirmation of CD (37.5% of patients). Diabetes imbalance, as evidenced by elevated HbA1c, was associated with the presence of CD (G1: 10.4±3.1%, G2: 11.9±2.1%; P = 0.001). Hypoglycemia was more frequent in patients with CD (G2 of 3.1 episodes/patient/week, G1:1.7 episodes/patient/week, P = 0.01).
Conclusion: The association of CD and T1DM is frequent and exposes this population to diagnostic, therapeutic and psychological difficulties. Appropriate therapeutic education is imperative to preserve the prognosis of these patients.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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