ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Characteristics of diabetic ketoacidosis episodes treated at HUC between 2021 and 2023
Óliver Quintero Rodríguez 1 , Selena Rodriguez Fernandez 1 , Kevin David Díaz Gorrín 1 , Javier Panizo Fra 1 , Ana Paola León Ocando 1 , Laura Mesa Suárez 1 , Elena Rodríguez Sosa 1 , Patricia León González 1 , Macarena Sánchez-Gallego Alonso 1 & Patricia Cabrera García 1
1Hospital Universitario de Canarias, Endocrinology and Nutrition, San Cristóbal de La Laguna, Spain
JOINT3417
Introduction and Objectives: Diabetic ketoacidosis (DKA) is one of the acute complications of diabetes mellitus. It is more common in patients with type 1 diabetes mellitus (T1DM), although cases have also been reported in patients with type 2 diabetes mellitus (T2DM) and latent autoimmune diabetes in adults (LADA). DKA can be triggered by poor adherence to treatment, new-onset diabetes, or secondary to an infection. The objective of this study is to describe the characteristics of DKA episodes attended at the Hospital Universitario de Canarias (HUC) between 2021 and 2023.
Materials and Methods: A descriptive observational study was conducted on a sample of 41 DKA episodes evaluated by the Endocrinology and Nutrition Department of HUC between 2021 and 2023. Variables analyzed included age, sex, type of diabetes, biochemical parameters (blood glucose, pH, ketonemia, bicarbonate), HbA1c, treatment, and associated comorbidities.
Results: Of the 41 patients, 23 (56%) were women and 18 (44%) were men, with a mean age of 34 years. A total of 28 patients (68%) had T1DM, including 4 newly diagnosed cases, while 8 patients (19%) had T2DM and 5 (13%) had LADA. Among the associated comorbidities, 29% had diabetic retinopathy, and 14% had diabetic nephropathy. The most frequent triggers of DKA were insulin omission and infections (30% each, totaling 60%), followed by undertreatment (17%, more common in T2DM patients), substance abuse (12%), and new-onset diabetes (10%). The average pH upon arrival was 7.11, with a mean blood glucose level of 390 mg/dL, a mean ketonemia of 4.8 mmol/l, and a mean bicarbonate level of 7.75 mmol/l. The mean HbA1c level measured before the event (in most cases, approximately 4 months prior) was 10.92%, while the mean HbA1c after the event was 11.71%. Regarding electrolyte imbalances, the most frequent was hyponatremia (48%), followed by hypokalemia (43%).
Conclusions: DKA has a mortality rate of <5%, which is even lower in our country, likely due to the rapid clinical management facilitated by the availability of appropriate infrastructure and resources. Nevertheless, the incidence of DKA remains significant. The poor metabolic control reflected in the high HbA1c levels prior to the event may have been influenced by loss of follow-up and less strict monitoring secondary to the COVID-19 pandemic.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more