ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Time in tight range (TITR) stratified by coefficient of variation (CV) in a cohort of patients with type 1 diabetes mellitus and multiple daily injections. a real-life study
Sandra Herranz-Antolín 1 , Sofía Ramos-Garrido 1 , Verónica Esteban-Monge 1 , Clara Cotón-Batres 1 , María Covadonga López-Virgos 1 , Marta Cano Megias 1 & Miguel Torralba 1
1Hospital Universitario de Guadalajara, Guadalajara, Spain
JOINT1205
Objetive: To analyze the TITR (70-140 mg/dL) and assess their possible differences according to CV in a cohort of type 1 DM patient with MDI.
Patients and Methods: 355 adult users of isCGM with at least a HbA1c during the period October 1, 2023-October 1, 2024, and glucose data in the 90 days prior (or at least 60 days) were included.
Results: Age 46.9 years (SD 13.6); 57.2% male; age at diagnosis 25.6 years (SD 14.3); time of evolution 21.6 years (SD 12.6); HbA1c 7.2% (SD 1.1). Glucometric parameters: glucose 165.9 mg/dL (SD 31.5), TITR 38.4% (20.3% had a TITR ≥ 50%), TIR (70-180 mg/dL) 60.4% (SD 16.5), TBR1 (54-69 mg/dL) 3.3% (SD 2.8), TBR2 (< 54 mg/dL) 0.5% (SD 0.8), TAR1 (181-250 mg/dL) 23.3% (SD 8.4), TAR2 (> 250 mg/dL) 12.4% (SD 12.1), CV 37.1% (SD 6.2), GMI 7.3% (SD 0.8) and GRI 47.8% (SD 21).
| CV ≤ 36% (n = 156) | CV > 36% (n = 199) | P | |
| Age (years) | 48.3 (SD 13.6) | 45.9 (SD 13.5) | 0.094 |
| Gender (male) (%) | 59.4 | 56.1 | 0.534 |
| Age at diagnosis (years) | 27.5 (SD 14.7) | 24.1 (SD 13.8) | 0.029 |
| Time of evolution (years) | 21.1 (SD 13.5) | 21.9 (SD 11.9) | 0.482 |
| Mean glucose (mg/dL) | 151.4 (SD 35.1) | 169.4 (SD 27.4) | 0.022 |
| TITR (%) | 40.8 (SD 16.4) | 36.4 (SD 10.4) | 0.008 |
| TITR ≥ 50% (%) | 31.4 | 11.6 | < 0.001 |
| TIR (%) | 65.5 (SD 19.8) | 56.5 (SD 12.1) | < 0.001 |
| TBR1 (%) TBR2 (%) | 1.9 (SD 2.4) 0.2 (SD 0.4) | 4.4 (SD 2.6) 0.8 (SD 0.9) | < 0.001 < 0.001 |
| TAR1 (%) TAR2 (%) | 23.1 (SD 11.1) 9.3 (SD 13.3) | 23.5 (SD 5.7) 14.8 (SD 10.4) | 0.667 < 0.001 |
| CV (%) | 31.5 (SD 3.3) | 41.5 (SD 4.1) | < 0.001 |
| GMI (%) | 7.2 (SD 0.8) | 7.4 (SD 0.7) | 0.022 |
| GRI (%) | 38.1 (SD 22.8) | 55.5 (SD 15.8) | < 0.001 |
| HbA1c (%) | 7.1 (SD 1.2) | 7.3 (SD 0.9) | 0.049 |
| The correlation TITR-TIR was high and differs depending on CV (patients with CV ≤ 36%: β = 0.88; CI 95% 0.83-0.93; R2 Adjusted 0.89; P< 0.001 – patients with CV > 36%: β = 0.84; CI 95% 0.81-0.87; R2 Adjusted 0.94; P< 0.001) | |||
Conclusions: The percentage of patients achieving TITR ≥ 50% is higher in patients with lower glycemic variability. The correlation TITR-TIR is high and modified by glycemic variability.
Volume 110
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