Dietary impact on the onset of MASLD in patients living with type 2 diabetes

Yesmine Elloumi; Mouna Elleuch; Khouloud Boujelben; Younes Derbel; Mouna Mnif; Salah Dhoha Ben; Majdoub Nabila Rekik

doi:10.1530/endoabs.110.EP496

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Endocrine Abstracts (2025) 110 EP496 | DOI: 10.1530/endoabs.110.EP496

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Dietary impact on the onset of MASLD in patients living with type 2 diabetes

Yesmine Elloumi ¹ , Mouna Elleuch ¹ , Khouloud Boujelben ² , Younes Derbel ² , Mouna Mnif ² , Dhoha Ben Salah ² & Nabila Rekik Majdoub ¹

Author affiliations

¹Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia; ²Hedi Chaker University Hospital, Sfax, Tunisia

JOINT421

Background: As the prevalence of MASLD rises, understanding the dietary factors contributing to its development is becoming crucial. Diet plays a critical role in metabolic health, yet its precise effect on the development of MASLD remains underexplored. This study aims to evaluate the impact of dietary intake on the onset of MASLD in people with T2DM.

Methods: This retrospective study included 202 T2DM patients, followed up to 2024 at the Endocrinology-Diabetology Department of Hedi Chaker University Hospital in Sfax, Tunisia. Patients were divided into two groups based on the presence or absence of hepatic steatosis on imaging :

• Group 1: 101 T2DM patients with MASLD• Group 2: 101 T2DM patients without MASLDFor each patient, we assessed macronutrient intake, including daily caloric intake in Kcal, as well as the percentage of daily intake from lipids, proteins, and carbohydrates. Additionally, we evaluated the intake of saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids. Thus, We assessed micronutrient intake, including fiber (g/day), iron (mg/day), calcium (mg/day), and cholesterol (mg/day).

Results: The total energy intake was similar between groups 1 and 2 (2125 [1900-2585] versus 2100 [1700-2400] kcal/day, respectively ; P = 0.251). In terms of macronutrients, carbohydrate intake was significantly higher in Group 1 compared to Group 2 (53% [50%-57%] versus 52% [48%-54%], respectively; P = 0.044). No statistically significant differences were observed for protein intake (P = 0.080), fat intake (P = 0.302) whether considering saturated, mono-unsaturated, or poly-unsaturated fatty acids (P = 0.403, P = 0.225, P = 0.896, respectively). Regarding micronutrients, daily intakes of iron, calcium, dietary cholesterol, and fiber were comparable between the two groups.

Conclusion: Our study aims to provide insights into potential nutritional interventions for prevention and management of MASLD within T2DM patients, offering avenues for targeted dietary strategies.