ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)
Association between neutrophil-to-lymphocyte ratio and metabolic syndrome in diabetic patients: a cross-sectional study
Oumaima Dimassi 1 , Houcem Elomma Mrabet 1 , Najoua Lassoued 1 , Maryem Souissi 1 , Nada Hassairi 1 , Boubaker Fadia 1 , Alaya Wafa 1 & Sfar Mohamed Habib 1
1Endocrinology-Diabetology and Internal Medicine Department; Tahar Sfar University Hospital Mahdia, Mahdia, Tunisia
JOINT2403
Introduction: Metabolic syndrome (MetS) is a cluster of risk factors that significantly increase the risk of cardiovascular diseases and type 2 diabetes. Inflammation plays a key role in the pathogenesis of MetS, and the neutrophil-to-lymphocyte ratio (NLR), a marker of systemic inflammation, has been linked to various metabolic disorders. This study aims to investigate the relationship between NLR and MetS, exploring its potential as an early biomarker for risk stratification.
Methods: A cross-sectional study was conducted, including 50 diabetic patients hospitalized at the Endocrinology Department of Mahdia from January to April 2024.
Results: The average age of participants was 54 ± 21 years, with a predominance of females (79.2%). Two thirds of the patients were diagnosed with type 2 diabetes, 24% were obese, and 23.7% had established cardiovascular disease. Hypertension was present in 28.9% of patients. Metabolic syndrome was observed in 50% of the patients. The average waist circumference was 84 cm. The median values of various metabolic parameters (in mmol/l) were as follows: fasting glucose (11.3), triglycerides (1.41), HDL-C (1.07). NLR did not significantly differ across BMI groups (P = 0.266). Additionally, no significant correlation was found between NLR and HbA1c (P = 0.193), fasting blood glucose (FBG) (P = 0.259), HDL cholesterol (P = 0.139), and triglycerides (P = 0.624). NLR was significantly higher in patients with hypertension (2.47 [1.78-7.56] vs 1.6 [1.2-2.29]; P = 0.029). No significant correlation between NLR and metabolic syndrome was observed (P = 0.405).
Conclusion: Our study suggests that while NLR is elevated in patients with hypertension, it does not correlate significantly with metabolic syndrome or other key metabolic parameters. Further research with a larger sample size and longitudinal design is needed to clarify the role of NLR as a potential biomarker for metabolic disorders.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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