Specificities by gender of macroangiopathic complications in type 2 diabetic patients

Takoua Moussa; Chaima Jemai; Insaf Jameleddine; Nesrine Dhieb; Ali Zohra Hadj; Olfa Laajili; Imen Hedfi; Yosra Htira; Mami Faika Ben

doi:10.1530/endoabs.110.EP517

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Endocrine Abstracts (2025) 110 EP517 | DOI: 10.1530/endoabs.110.EP517

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Specificities by gender of macroangiopathic complications in type 2 diabetic patients

Takoua Moussa ¹ , Chaima Jemai ¹ , Insaf Jameleddine ¹ , Nesrine Dhieb ¹ , Zohra Hadj Ali ¹ , Olfa Laajili ¹ , Imen Hedfi ¹ , Yosra Htira ¹ & Faika Ben Mami ¹

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¹Institute of Nutrition of Tunis, C Department, Tunis, Tunisia

JOINT3945

Introduction: Although the mechanisms and risk factors for macroangiopathies in type 2 diabetic (T2D) patients are similar between genders, clinical and epidemiological differences may influence their prevalence and management. This study aimed to investigate the association between macroangiopathic complications and gender.

Materials and Methods: A study was conducted on 70 T2D patients, divided into two groups: Group 1 (G1) with 35 women and Group 2 (G2) with 35 men, matched by age, diabetes duration, and HbA1c levels. Clinical and biological data were collected from medical records.

Results: The average age was 56.7 ± 7.5 years. The mean diabetes duration was 11.7 ± 5.1 years, with an average HbA1c of 10.2 ± 1.1%. A total of 82.9% of women and 62.9% of men had no macroangiopathic complications. Single macroangiopathy was observed in 11.4% of women and 5.7% of men (P = NS). Two macroangiopathies were present in 31.4% of women and 5.7% of men (P = NS). No patients had more than two macroangiopathies. The prevalence of coronary artery disease (CAD) was identical in both groups (11.4%). Stroke and peripheral artery disease (PAD) were more frequent in men, with a prevalence of 11.4% and 17.1%, compared to 5.7% and 2.9% in women, respectively (P = NS). A significant association was found between CAD and hypertension in men (P = 0.041) but not in women (P = 0.326).

Conclusion: The simultaneous presence of multiple macroangiopathies, PAD, and stroke was more frequent in men. Additionally, hypertension could be a predictive factor for CAD in the male population. That’s why more frequent screening in this group seems to be necessary.