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Endocrine Abstracts (2025) 110 EP644 | DOI: 10.1530/endoabs.110.EP644

1Hospital Universitario Doctor José Molina Orosa, Arrecife, Spain


JOINT1547

Primary thyroid sarcoma is a rare tumor. It confers a poor prognosis due to its metastatic capacity. Differential diagnosis is a challenge due to its low prevalence. We present the case of a primary thyroid sarcoma in a 71-year-old female patient admitted for upper airway obstruction related to a voluminous mass dependent on the left thyroid lobe with thrombosis of the internal jugular vein. In addition, the CT scan shows two nodules in the right lung. She required admission to the intensive care unit requiring tracheostomy due to the unresectability of the tumor. The results of the incisional biopsy showed data compatible with primary high-grade thyroid sarcoma. During hospitalization she had two episodes of airway obstruction with admission to the ICU for poor secretion management. In addition she had an urinary tract infection by Klebsiella pneumoniae ESBL and febrile neutropenia after oncological treatment was started. She was discharged after speech therapy rehabilitation and after receiving adequate nutritional support. She is currently being treated with doxorubicin. According to epidemiology, only 142 cases of primary thyroid sarcoma have been described in the medical literature. Given its rarity, there are no imaging techniques to differentiate it from other common thyroid tumors. The differential diagnosis should be made with thyroid lymphoma and anaplastic thyroid cancer. Its treatment is based on the pillars of surgery, chemotherapy and radiotherapy, although there is still no defined line. The clinical manifestations consisting of a rapid increase of a painless mass in the neck with obstruction of the airway should make us consider this extremely rare and aggressive entity.

Volume 110

Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course

European Society of Endocrinology 
European Society for Paediatric Endocrinology 

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