Metabolic risk factors in overweight women with polycystic ovary syndrome: results of a tunisian study

Sana Khamassi; Kamilia Ounaissa; Taieb Ach; Ramla Mizouri; faten mahjoub; Haifa Abdesselem; Yasmine Fakhfakh; Emna Bornaz; Brahim Asma Ben; Rym Yahyaoui; Jamoussi Henda; Chiraz Amrouche

doi:10.1530/endoabs.110.EP971

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Endocrine Abstracts (2025) 110 EP971 | DOI: 10.1530/endoabs.110.EP971

ECEESPE2025 ePoster Presentations Metabolism, Nutrition and Obesity (164 abstracts)

Metabolic risk factors in overweight women with polycystic ovary syndrome: results of a tunisian study

Sana Khamassi ¹ , Kamilia Ounaissa ¹ , Taieb Ach ² , Ramla Mizouri ³ , faten mahjoub ³ , Haifa Abdesselem ¹ , Yasmine Fakhfakh ¹ , Emna Bornaz ¹ , Asma Ben Brahim ¹ , Rym Yahyaoui ¹ , Jamoussi Henda ³ & Chiraz Amrouche ¹

Author affiliations

¹National Institute of Nutrition and Food Technology, Department of Nutritional Diseases D, Tunis, Tunisia; ²Farhat Hached Hospital, Department of Endocrinology and Diabetology, Sousse, Tunisia; ³National Institute of Nutrition and Food Technology, UR17SP01-Clinical Biology Laboratory, Tunis, Tunisia

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Background: Given the growing evidence linking Polycystic Ovary Syndrome (PCOS) with metabolic risk factors, understanding the specific metabolic profiles in overweight women with PCOS is essential for developing effective management strategies [1]. Therefore, the aim of our study was to assess metabolic risk factors in a group of overweight women with PCOS.

Methods: This was a descriptive, cross-sectional, and retrospective case-control study involving 61 overweight women within the reproductive age range, divided into two groups: 31 women with PCOS and 30 women without PCOS. The groups were matched for age and body mass index (BMI). Clinical and biological data were extracted from the patients’ medical records.

Results: The mean age at diagnosis of PCOS was 23.4±7.3 years, with extremes ranging from 14 to 39 years. Hirsutism, alopecia, and acne were observed in 78%, 60%, and 45% of PCOS patients, respectively. Biological hyperandrogenism was found in 66% of the patients with PCOS. Regarding menstrual cycle disorders, amenorrhea, oligomenorrhea, and infertility were observed in 54%, 47%, and 19% of cases, respectively. The majority of patients with PCOS had phenotype A (81%), while 19% had phenotype C. Among the patients with PCOS, 44% were treated with dydrogesterone and 28% were on metformin. Our study revealed a significantly higher frequency of type 2 diabetes in patients with PCOS compared to the control group (97% vs 18%; P = 0.0001). However, fasting blood glucose, HbA1c, and the HOMA index were comparable between the two groups (P = 0.06, P = 0.13, and P = 0.71, respectively). Women with PCOS had a significantly higher frequency of hypertension (90% vs 19%; P = 0.0001), metabolic syndrome (97% vs 54%; P = 0.0001) and dyslipidemia (90% vs 54%; P = 0.002) compared to the control group. The lipid profile parameters were similar in the two groups.

Conclusion: Our findings emphasize the need for targeted metabolic risk management in overweight women with PCOS. Early identification and intervention are crucial to reducing the long-term health risks associated with this condition.

References: 1. Yu J, Zhou Y, Ding J, Zhang D, Yu C, Huang H. Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome. Front Endocrinol (Lausanne) 2023;13:970733.