ECEESPE2025 Poster Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Changes in reproductive hormones in the years before diagnosis of testicular cancer
Nina Mørup 1,2 , Trine Holm Johannsen 1,2 , Gedske Daugaard 3 , Jørgen Holm Petersen 1,2,4 , Christian Erikstrup 5,6,7 , Erik Sørensen 8 , Sisse Rye Ostrowski 8,9 , Ole Birger Pedersen 9,10 , Kristian Almstrup 1,2,11 & Anders Juul 1,2,9
1Department of Growth and Reproduction, Copenhagen University Hospital– Rigshospitalet, Copenhagen, Denmark; 2International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen, Denmark; 3Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; 4Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark; 5Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; 6Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 7Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Aarhus, Denmark; 8Department of Clinical Immunology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; 9Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 10Department of Clinical Immunology, Zealand University Hospital - Køge, Køge, Denmark; 11Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
JOINT815
Testicular germ cell tumors (TGCTs) are the most common malignancy found in young men. They arise from the precursor cells, germ cell neoplasia in situ, which are hypothesized to be present in the testes already at birth. Since reproductive hormone levels are affected in patients with a TGCT, we hypothesized that changes in reproductive hormone levels were detectable even before their primary TGCT diagnosis. We measured the concentrations of reproductive hormones (FSH, LH, inhibin B and AMH) in plasma samples from 72 Danish blood donors and participants in the Danish Blood Donor Study (DBDS), 1-20 samples from each, donated up to 11 years before they were diagnosed with a TGCT. We also measured reproductive hormones in 72 sex- and age-matched controls from DBDS. Within one year prior to the primary diagnosis, we found significantly higher concentrations of FSH (P = 0.033) and lower concentrations of inhibin B (P = 0.009) and AMH (P = 0.019) in patients compared with controls. In patients with the histological subtype seminoma, FSH standard deviation (SD) scores were higher (P < 0.001) and inhibin B SD scores lower (P = 0.001) compared with controls. In patients with non-seminomas, LH SD scores were significantly lower (P = 0.021) compared with controls. Significant differences in FSH, inhibin B and AMH SD scores were evident up to three years before diagnosis of a TGCT compared with controls. Lastly, higher FSH and LH and lower inhibin B SD scores (P = 0.003, P = 0.047, and P = 0.032, respectively) were observed in patients with seminomas compared with patients with non-seminomas. In conclusion, changes in reproductive hormone concentrations and sex- and age-adjusted SD scores are evident in patients several years prior to a primary diagnosis of a TGCT, suggesting a gradual reduction in testicular function prior to diagnosis. The observed changes are dependent on the histological subtype of the TGCT.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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