Endocrine Abstracts

JOINT1309

Introduction: Vitamin D plays a crucial role in bone and mineral homeostasis, but its effect on cardiovascular health and blood pressure (BP) in particular remains unclear with studies presenting conflicting results. Most studies have focused on hypertensive patients, but this study aims to assess the effect of cholecalciferol supplementation on BP in young men.

Materials and methods: The Copenhagen Bone-Gonadal Study, a double-blinded RCT (NCT01304927), included 330 healthy infertile men with 25(OH)D₃ insufficiency who received either cholecalciferol supplementation or placebo for 150 days. The primary endpoint was semen quality. BP was measured using standardized conditions after five minutes of rest, with an average of three consecutive measurements used for analysis. Correlations between vitamin D metabolites and BP were assessed using Pearson’s correlation, and intervention effects were analyzed using t-tests and ANOVA.

Results: The cohort consisted of 300 men (mean age 35 years), and no correlations were found between systolic BP and 25(OH)D₃ (r=0.037, P=0.53) or 1,25(OH)₂D₃ (r=−0.0042, P=0.94) at baseline. There was no difference between the treatment and placebo groups after 150 days in systolic BP (127 mmHg vs 127 mmHg, P=0.87) or diastolic BP (81 mmHg vs 82 mmHg, P=0.23). Even in men with vitamin D deficiency (<25 nmol/l), supplementation with cholecalciferol and calcium did not affect BP (127 mmHg vs 127 mmHg, P=0.85). No differences were found in subgroups when stratifying according to baseline 25(OH)D₃ levels, SCORE2 categories, or changes in in serum 25(OH)D₃ (all P > 0.05).

Conclusion: There was no correlation between vitamin D metabolites and BP. Cholecalciferol supplementation for 150 days did not significantly affect BP in infertile men, regardless of baseline 25(OH)D₃ status or cardiovascular risk using SCORE2, implying that high-dose supplementation is not beneficial for BP regulation in young and overall healthy men.