ECEESPE2025 Poster Presentations Adrenal and Cardiovascular Endocrinology (169 abstracts)
Persistent renin suppression after unilateral adrenalectomy in patients with primary aldosteronism
Isabel Stüfchen 1 , Júnia Ribeiro de Oliveira Longo Schweizer 1 , Friederike Völter 1 , Stephanie Zopp 1 , Denise Bruedgam 1 , Petra Zimmermann 2 , Tracy Ann Williams 1 & Martin Reincke 1
1Department of Medicine IV, Endocrinology, Diabetology and Metabolism, LMU University Hospital, LMU Munich, Munich, Germany; 2Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany
JOINT1698
Background: Suppressed renin levels in medically treated patients with primary aldosteronism (PA) are associated with a worse cardiometabolic outcome. This study investigates the prevalence and outcome of persistent renin suppression after adrenalectomy in patients with unilateral PA.
Methods: We included 77 patients that underwent adrenalectomy for PA and evaluated postoperative renin recovery. Patients were divided into tertials based on their renin concentration at the first follow-up, approximately six months after adrenalectomy. We compared histopathology using CYP11B2 staining according to histopathology of primary aldosteronism consensus (HISTALDO), biochemical and clinical outcomes according to the PASO (Primary Aldosteronism Surgical Outcome) criteria and improvement of comorbidities and end-organ damage at short- and long-term follow-up ranging from six months to three years postoperatively.
Results: Renin concentrations were <8mU/l, between 8 and 16mU/l, or >16mU/l at first follow-up in the respective groups. Patients with renin concentrations <8mU/l had twice as often non-classical histopathology, comprising multiple aldosterone-producing nodules, aldosterone-producing micronodules and aldosterone-producing diffuse hyperplasia, as the other two groups together (8/26 (30.8%) vs. 1/25 (4%) vs. 3/26 (11.5%); P=0.024) and less frequently complete biochemical remission (normalisation of aldosterone-to-renin ratio and correction of hypokalaemia) at their first follow-up (P<0.01). There were no differences in the clinical outcome, long-term biochemical outcome, and improvement of end-organ damage and comorbidities.
Conclusions: In our study, suppressed renin concentrations <8mU/l occurred in one third of PA patients six months after adrenalectomy. Despite a worse short-term biochemical outcome, long-term biochemical and clinical outcomes, including comorbidities and end-organ damage, do not appear to be associated with postoperative renin concentrations.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more