IES2025 Research, Audit and Quality Improvement Projects E-Posters (60 abstracts)
Vitamin D therapy does not worsen hypercalcaemia in primary hyperparathyroidism
Mairé T Crowley , Deirdre Green , Ruth Cullen , Maria Byrne , Mensud Hatunic , Brendan Kinsley , Recie Davern , Siobhán McQuaid , Paula M. O’Shea & Nigel Glynn
Mater Misericordiae University Hospital, Dublin, Ireland
Primary hyperparathyroidism (PHPT) is characterised by inappropriately elevated parathyroid hormone (PTH) levels, leading to reduced bone mineral density (BMD). Deficiency of 25-hydroxyvitamin D can further raise PTH and potentially worsen parathyroid bone disease in medically managed patients. For such patients, vitamin D levels above 75 nmol/lare recommended, though the optimal management approach remains unclear. We assessed vitamin D status in individuals attending our centre, aiming to determine the use of supplementation and its effect on plasma adjusted calcium. Vitamin D prescriptions and levels at diagnosis and last follow-up were reviewed for 90 patients. The mean age was 66.3 ± 11.7 years, with an average 5.6 ± 3.3 years since PHPT diagnosis. At diagnosis, 11 patients (12%) were receiving vitamin D. 25-hydroxyvitamin D levels above 50 nmol/land 75 nmol/lwere found in 58 (64%) and 33 (37%) patients, respectively. Thirty-six patients (40%) commenced vitamin D supplementation, with a mean daily dose of 855 ± 237 IU over 3.8 ± 3.1 years. No significant changes were observed in adjusted calcium (2.68 ± 0.06 vs 2.69 ± 0.06 mmol/l/l, P = 0.39), phosphate (0.85 ± 0.13 vs 0.88 ± 0.16 mmol/l/l, P = 0.26), or PTH (11.7 ± 4.5 vs 11.0 ± 4.3 pmol/l, P = 0.17). Current mean 25-hydroxyvitamin D level is 80 ± 33 nmol/l. Additional therapies included cinacalcet (n = 6), bone protection agents (n = 10), and combined treatment (n = 5). These findings suggest that maintenance-dose vitamin D supplementation in PHPT does not significantly alter plasma adjusted calcium, phosphate, or PTH levels over the observed treatment period.
Volume 115
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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