IES2025 Research, Audit and Quality Improvement Projects E-Posters (60 abstracts)
Pregnancy outcomes in women aged 35 years and older with singleton pregnancies complicated by gestational diabetes
Christine Newman 1,2,3 , Navanit Shine 1 , Louise Carmody 3 , Mairead Crowley 3 , Breda Kirwan 3 , Lorraine McDermott 3 , Roberta Scairati 1,2 , Paula O’Shea 1,2,3,4 & Fidelma Dunne 1,2,3
1College of Medicine, Nursing and Health Sciences, University of Galway, Ireland; 2HRB Clinical Research Facility Galway, University of Galway, Co Galway, Ireland; 3Galway University Hospital, Newcastle Road, Co Galway, Ireland; 4Department of Biochemistry, University College Dublin, Ireland
Pregnancy in women >35 years is a key risk factor for GDM and is associated with additional complications. The aim of this research is to analyse the outcomes of pregnant women > 35 years and to compare the pregnancy outcomes of this cohort with those aged 18-34 diagnosed with GDM. We retrospectively reviewed our electronic medical records for all women with GDM from 2016-2020. We collected data on age, ethnicity, GDM risk factors (BMI), maternal and fetal outcomes including gestational age at delivery, preeclampsia, birth weight, large and small for gestational age births and congenital anomaly. From 2016-2020, 1260 women were diagnosed with GDM. In total 607 (48.2%) were aged 18-34 years (median age 31.8, interquartile range 4.4) and 51.8% (n = 653) were >35 years (median age 38.1, 3.6). 30% overweight and 40% obese. There was no difference between groups in previous GDM, PCOS, family history or fertility treatment. Those aged >35 years were twice as likely to develop pre-eclampsia (P < 0.01), more likely to have a Caesarean birth (46.2% vs 39.2%, P < 0.05) and preterm birth (9.8 vs 5.9%, P < 0.05). No difference were seen in birthweight (3440g vs 3460 g), small for gestational age (7%) or large for gestational births (10.2% vs 12.1%). There was also no difference in neonatal care, congenital anomaly or glycaemic management determined by HbA1c. We identified higher rates of pre-eclampsia, Caesarean birth and prematurity in women with GDM aged >35 years. Advanced maternal age confers additional risks to GDM pregnancies.
Volume 115
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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