Endocrine Abstracts

Introduction: Hirsutism is the presence of excess hair growth in females as a result of increased androgen production and/or increased skin sensitivity to androgens. In a postmenopausal female presenting with hirsutism, a high level of clinical suspicion, a detailed history and physical examination, substantiated by focused biochemical and morphological confirmation is necessary.History: The authors present a case of a female with a longstanding history ...

Background: Paragangliomas of head and neck (HNPPGLs) are rare and mostly slow growing tumors arising from neural crest-derived cell clusters and have high rate of genetic mutation, up to 40% germline mutations and 30% somatic mutations.Methods: Retrospective review of institutional experience with clinical evaluation and management of HNPPGLs.Results: Among 174 patients with HNPPGLs diagnosed from 1981 to 2023, 116 (67%) were wome...

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...

Fetal events can affect adult testosterone levels but how this occurs is unknown, as adult Leydig cells (ALC) do not differentiate until puberty. Qin et al. 2008 (PLos ONE) identified that chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is essential postnatally for ALC development. We hypothesized that: i) COUP-TFII+ non-Leydig interstitial cells are progenitors for ALC and are present in the fetal testis, ii) these ‘pr...

Pituitary adenomas account for ~10% of intracranial tumors and result in morbidity due to both altered hormonal patterns as well as side effects of therapy. Currently, great attention has been given to preventive strategies, and in this context, the use of functional foods with chemopreventive compounds appears to contribute much in this process. Among these substances, we highlight the consumption of carotenoids is associated with reduced risk of chronic diseases including ca...

Objective: We will analyze various characteristics of the patients who attend the HUMV Diabetic Foot Unit for a week. The variables studied are sex, age, type of diabetes, years of evolution, type of current treatment, last glycosylated hemoglobin, presence of other cardiovascular risk factors and existence of previous ulcerations and amputationsMaterial and Methods: We worked with Microsoft Excel to coollect the data and perform the statistical study.</...