Endocrine Abstracts

Background: When US characteristics and the diameter of a thyroid nodule (TN) justify further evaluation to rule out or to establish the diagnosis of thyroid cancer (TC), fine needle aspiration (FNA) biopsy for cytology (FNAC) is indicated. A major limitation of FNAC is the high rate of indeterminate significance (~30%) results, which require further evaluation. Although recently introduced molecular testing contributed to the ability to differentiate benign from malignant TNs...

Three independent studies identified SNPs in the first intron of the gene FTO as being strongly and consistently associated with BMI and/or obesity at significance levels (P=10−7 to P=10−30) unobserved so far in genetics of obesity. The three studies estimated the putative effect around 1% of the total variance of BMI. So far, this represents the strongest effect for a common variant in obesity.This result ...

Actuality: According to the International Classification of Sleep Disorders in type 2 diabetes, the risk of obstructive sleep apnea (OSA) in middle-aged people ranges from 18% to 36%. In a report by S. D. West et al. the incidence of sleep apnea in patients with diabetes is estimated at 23% compared with 6% in the general population. In a recent study, AS Peltier et al. it was found that 79.2% of patients with OSA had a violation of glucose tolerance and 25% were first diagnos...

Phaeochromocytomas are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. We report a 68-year-old female who was found to have a locally arising colonic adenocarcinoma on biopsies. Staging also identified a 10.7 cm right adrenal lesion and work-up revealed markedly raised urinary metanephrines and positive MIBG imaging. The MDT decision was to first remove the colonic cancer with appropriate alpha blockade. It was felt that a comb...

Introduction: Percutaneous Ethanol Injection (PEI) is well known treatment for benign cystic thyroid nodules; however, local pain is common side effect. Objective: To compare between efficacy and safety of Percutaneous Polidocanol Sclerotherapy (PPS) vs PEI.Patients and methods: We included 60 patients -with mean age 32 years- have benign thyroid nodules (9 of them were males). They were divided into 2 groups; group 1 with...

Background: Nowadays, single nucleotide polymorphisms in genes KISS1, KISS1R, MKRN3, DLK1 have been described as the leading cause of precocious hypothalamic-pituitary axis activation in children. Genetic testing in patients with hereditary forms of precocious puberty (PP) can expand our knowledge in underlying molecular mechanisms of the disease. The diagnosis of genetic bases is necessary for genetic counselling.Aim: To access clinical charact...

Phaeochromocytoma and paragangliomas (PH/PG) are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. The Phaeochromocytoma of the Adrenal gland Scaled Score (PASS) is used to separate benign from malignant lesions with a score > 4 showing potential for biologically aggressive behaviour. Pre-operatively, MIBG together with CT/MRI remain the diagnostic radiological gold standard.We report a 68-year-old fema...

Introduction: Recent observational evidence suggests strong links between low vitamin D levels and a range of cardiovascular risk factors, including hypertension, diabetes, obesity and hyperlipidemia. In addition increased rate of all-cause and cardiovascular mortality.Objectives: To determine 25-hydroxyvitamine D (25(OH) D) levels as well as its relationship with some cardiovascular risk factors among Egyptian Female patients with type 2 diabetes.<p...

Objectives: Primary aldosteronism (PA) is considered to be the most common cause of secondary hypertension. Therefore, a relevance of early diagnosis of PA is obvious.Methods: We evaluated 98 patients with hypertension in age 47.8±1.4 years. We measured serum potassium by indirect porentiometry, serum aldosterone and plasma rennin activity (PRA) by RIA, serum corticosterone (B), 18-hydroxycorticosterone (18-OH-B), 11-deoxycorticosterone (DOC), 11-de...

Hyponatraemia is the commonest electrolyte abnormality observed in clinical practise. It is a potential cause of substantial morbidity and mortality. Drug history, fluid volume status in addition to serum and urine biochemistry is essential for optimal management.We report a case of a 50-year-old female with known psychosis admitted to the Mental Health Unit and treated with Citalopram, Mirtazepine, Risperidone, Clonazepam and Procyclidine. Admission pla...