Endocrine Abstracts

Introduction: Sheehan’s syndrome or Simmond’s disease is a partial or complete postpartum hypopituitarism caused by pituitary infraction and necrosis that usually occurs as a complication of massive postpartum hemorrhage or severe hypotension during or after labor and delivery. We present the case of Sheehan’s syndrome presenting postpartum depression. Case: A 40 years old woman, referred to our department by her psychiatrist for explorati...

Background: Most phaeochromocytomas are unilateral and are not associated with a neuroendocrine syndrome. Although these tumours are often histologically benign, they tend to have potentially lethal presentations.Case: A 51-year-old female presented in 2016 with headache, vomiting, palpitations, and a cardiac-sounding chest pain for 16 hours. Her ECG showed a junctional rhythm with generalised ST-segment depression. Acute coronary syndrome treatment was ...

A 21-year-old woman presented in 2015 with palpitations, weight and hair loss, mood swings and diarrhoea. She was diagnosed with thyrotoxicosis (Table). On examination, thyroid was normal and no evidence of opthalmopathy. Treatment with Propranolol and Carbimazole was commenced.  Ultrasound neck revealed moderate diffuse enlargement of the thyroid with uniformly abnormal echotexture, consistent with thyroiditis.  A month later, she developed profound hypothyroidism, therefore Carbimazole was ...

Ovarian cancer is one of the major cause of death among women worldwide with high incidence. Ovarian cancer can be categorized into epithelial, non-epithelial (germ cell and sex cord-stromal cell), and metastatic (usually develop from surrounding cancerous organs). Recently, several approaches have been studied to control ovarian cancer at the transcriptional or post-transcriptional levels using small non coding RNAs including microRNAs. We carried out a meta-analysis of previ...

Introduction: Thyroid carcinoma in childhood is rare, but may present with distant metastases. We present an unexpected diagnosis of follicular–variant papillary thyroid carcinoma (FVPTC) presenting to acute services with cyanosis.Case report: An 11-year old boy presented to A&E with a two month history of cyanosis, worse with exertion, but not associated with respiratory distress or limitation of exercise tolerance. He had peripheral cyanosis, ...

In June 2021, NHS England commissioned 15 Complications from Excess Weight (CEW) services to pilot Tier 3 paediatric weight management services in England. This study aimed to assess initial patient experiences / responses to weight management strategies delivered in a single CEW service between January-June 2022.Methodology: We conducted an online survey to assess patient experiences, motivators and barriers to healthy lifestyle change in 45 patients se...

Thyroid storm is rare and life threatening manifestation of thyroid hormone excess. It has high mortality rate with delayed treatment. As early intervention is associated with improved patient outcome, prompt diagnosis based on clinical grounds is of paramount importance. We present a case of thyroid storm which was different in terms of absence of fever on presentation, presence of thrombocytopenia and deranged cholestatic LFTs which resolved after treatment of thyroid storm....

Introduction: Subarachnoid haemorrhage (SAH) is associated with a mortality rate of 30% and the survivors face significant morbidity including fatigue, isolation, depression and sleep disorders; factors affecting general health related quality of life (QoL). QoL is also known to be decreased in pituitary-hypothalamic insufficiency and tends to improve after treatment. SAH has been suggested to be a common cause of hypopituitarism by some whereas not by others. We aimed to inve...

A 65-year-old gentleman was referred by his GP because of acute kidney injury and hypercalcaemia, which was associated with low levels of parathyroid hormone. He had been fit and well and was on no regular medications. Whilst his hypercalcaemia was partly correctible with saline rehydration, cautious use of bisphosphonates and cinacalcet were not effective in preventing rebound, and his nephropathy persisted. Curiously, he had longstanding low plasma alkaline phosphatase, but had normal denti...

Introduction and importance: Ovarian Sertoli-Leydig cell tumors (SLCT) are rare sex cord-stromal tumors, representing less than 0.5% of all ovarian malignancies. Typically diagnosed at a young age, with 75% of patients having an average onset age of less than 30, these tumors often present a management challenge due to their early detection in young women. The primary dilemma lies in striking the right balance between implementing an effective treatment to prevent recurrences ...