Endocrine Abstracts

Background: Overnight dexamethasone suppression tests (ONDST) are conducted to investigate patients with symptoms suggestive of cortisol hypersecretion or if an adrenal incidentaloma is identified. Cortisol levels of 50 nmol/l and above following ONDST may be related to autonomous cortisol secretion (ACS) and require further investigation. Determining likely presence of ACS is essential given reported associations with type 2 diabetes mellitus (T2DM), obesity, cardiovascular d...

Introduction: Short synacthan test is a first line endocrine test for diagnosing adrenal insufficiency except in situations like Pituitary surgery or Pituitary apoplexy within the last 2 weeks when this may give a false positive result and this is well known in literature. Here we discuss lesser reported clinical situations seen in two of our patients having good adrenal response to SST with only GST identifying adrenal insufficiency.Case Report: Two pat...

Introduction: Carbimazole is a first line antithyroid drug for thyrotoxicosis management in UK. Its main but rare complications include allergic reaction and risk of neutropenia. Here we discuss the lesser reported situation in which a thyrotoxic patient who is in a remission from Aplastic anaemia was treated with Carbimazole.Case Report: Out patient was seen in Ambulatory care with symptoms of heart failure along with tachycardia. Thyroid blood test sho...

Background: Following vaccination for SARS-CoV-2 a significant proportion of individuals experience moderate to severe symptoms. In patients with adrenal insufficiency (AI) this has been reported to translate in to need for increased glucocorticoids and incipient or frank adrenal crises. We assessed occurrence of symptoms, need for glucocorticoid dose adjustment and crises in a large cohort of patients with AI following vaccination for SARS-CoV-2.Methods...

Background: Pancreatic acinar cell carcinoma (PACC) is a rare cancer, comprising less than 1% of all pancreatic cancers and often presents as a mixed malignancy with a neuroendocrine component. Limited data exists on its clinical and molecular characteristics. This retrospective study aims to provide additional insights to better understand and characterize the disease.Methods: Patients from the Mayo Clinic with pathology records denoting pancreatic acin...

Background: Lu177 has shown efficacy in advanced NET with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time. In this study, we aimed to assess the prevalence of CH in NET patients (pts) prior to Lu177 along with the incidence of cytopenia in NET pts treated with lu177 based on the CH status at baselineMet...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrinopathy caused by inappropriate PTH secretion by the parathyroid glands, which leads to alterations in phosphocalcic metabolism. The aim of our study is to determine the prevalence of complications of PHPT.Materials and Methods: Retrospective descriptive study of 83 patients with primary hyperparathyroidism collected over a period of 07 years (between 2015 and 2022) in the endocrinology ...

Authors: Mohamed Coco, Katrina Sheikh, Basheir Osman, Jayadave Shakher: Department of Acute Internal Medicine, Birmingham Heartlands Hospital-University Hospitals BirminghamIntroduction: Although skeletal metastatic diseases have commonly been associated with hypercalcemia; we present a case of severe hypercalcemia secondary to extensive skeletal sclerotic metastatic disease.Case: ...

An 80-year old female was admitted to Ipswich Hospital with anorexia, constipation, thirst and fatigue. Her examination was unremarkable apart from 2 cm splenomegaly. Investigations revealed renal impairment (creatinine 293 umol/l), normal electrolytes along with hypercalcaemia (corrected Ca 3.54 mmol/l), normal PO4, normal CXR, PTH of 3.3 pmol/l (NR -normal range- 0.95–5.7 pmol/l) and protein electrophoresis was normal. Abdominal USS confirmed splenomegaly. Af...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...