Endocrine Abstracts

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Introduction: Hypertriglyceridemia induced pancreatitis (HIP) is an uncommon condition accounting for 1–4% of cases of acute pancreatitis, mostly associated with poor glycemic control in diabetic patients. Diabetic ketoacidosis (DKA) may complicate the clinical course of HIP; however, few studies have documented this association. Our objective was to identify clinical and demographic differences between HIP patients with co-existing DKA compared to those without DKA.<...

The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression of CD105, CD73, and CD90 that can differentiate into chondrocytes, osteoblasts, and adipocytes in vitro. They are known to have immunomodulatory capabilities. Our aim was to isolate and characterize the immunomodulatory capabilities of MSC from pituitary tumors (P...

Pituitary adenomas (PA) are primarily benign lesions with monoclonal origins from the adenohypophyseal cells and represent 10-15% of all intracranial tumors. Tumors derived from POU1F1 cell lineage are GH-, TSH-, and PRL-secreting tumors that cause important syndromes such as acromegaly, hyperthyroidism, and sexual dysfunction, respectively. Surgical resection is the first line of treatment; the secondary treatment is pharmacological; despite having targets pharmacological in ...