Endocrine Abstracts

In clinical settings, when biochemical screening revealed grossly elevated urinary normetanephrine and metanephrine in the presence of an adrenal mass, there is a high clinical suspicion of a pheochromocytoma. However, sulfasalazine, an anti-inflammatory drug can cause analytical drug interference, leading to falsely positive elevation of urinary normetanephrine and a misdiagnosis of phantom pheochromocytoma. This report illustrates two patients with adrenal mass who had false...

Introduction: In the Cardiff and Vale (C&V) Health Board, there are 203 children and young people (CYP) under the care of the multidisciplinary team (MDT), 96% of whom have T1DM. Every CYP is offered four outpatient clinic appointments every year, one of which is an annual review. The majority of them are situated in the University Hospital Wales (UHW) site, whereas the University Hospital Llandough (UHL) clinic was introduced in 2016 for easier access for the CYP from the...

BackgroundPatients with Subclinical Cushing’s Syndrome (SCS) share many similarities with those of metabolic syndrome. Several studies have shown variable prevalence of SCS in patients with diabetes and obesity of up to 9% suggesting that it may be more common in these patients. Our study aims to explore the prevalence of SCS in Malaysians with metabolic syndrome and examine any possible predicting factors.Methods<p class=...

Introduction: Follicular thyroid cancer (FTC) is a tumour of the thyroid epithelium with follicular differentiation and invasion into capsule or vessels. Constitutes 10% of all thyroid cancers, may be minimally or widely invasive. metastases in 20% of cases by haematogenous spread, rarely to lymph nodes. Twice as common in females as males, mean age 50years. Treated with thyroidectomy, radioactive iodine ablation and TSH suppression with levothyroxine.Ca...

We report a 32-year-old primigravida with type 2 diabetes and large uterine fibroid who was found to have incidental, asymptomatic, non-PTH driven hypercalcaemia of 2.67 mmol/l (NR 2.2-2.60 mmol/l) at 7 weeks gestation. Investigations revealed no evidence of malignancy. Interestingly, following initial blood test, her calcium normalised but with persistent complete suppression of PTH until 19 weeks gestation, when her calcium rose to 3.25 mmol/l. Her 1,25-dihydroxy Vitamin D w...

Introduction: Cushing’s syndrome can impair the gonadotrophic axis in women of child bearing age if left untreated. Furthermore undergoing endoscopic transphenoidal surgery can render patients hypogonadal, thereby reducing the chances of spontaneous conception. In such cases, pregnancy is usually achieved by assisted contraceptive techniques. We present a case of spontaneous pregnancy following transphenoidal surgery and bilateral adrenalectomy.Case...

Introduction: Hyponatraemia is a common electrolyte abnormality seen among hospitalised patients. We describe below, an inpatient seen with severe hyponatraemia.Case description: 71yr old gentleman with no co-morbidities, admitted with acute confusion and slurred speech. Physical examination: Observations: Temperature 35C, heart rate 53/min, otherwise stable. GCS 15/15, no focal neurolo...

Introduction: Vitamin D (Vit D) is required for maintaining optimal bone health and there is widespread campaign in the media for its use. There is however lack of awareness among the general public about therapeutic doses which if exceeded can result in harm. We present one such patient who was taking harmful quantities of vit D supplements procured over the internet which resulted in hypercalcaemia and renal failure.Case Description: 50year old lady, N...

Introduction: Diabetic nephropathy remains a major cause of morbidity and mortality for persons with diabetes mellitus. Globally, most patients with diabetes are in developing countries that do not have the resources or health infrastructure to provide universal renal replacement therapy. The ADA recommends that estimated glomerular filtration rate (eGFR) be calculated using serum creatinine for diabetics at least once a year.Objectives: To determine the...

Background: New emerging studies demonstrated that mortality from thyroid cancer and disease recurrence was significantly higher among Filipinos compared with other ethnic groups. However, exact mechanisms which could explain these findings among Filipino patients remain to be poorly understood. The risk factors associated with disease recurrence among adult Filipino patients with low-risk papillary thyroid cancer in Manila Doctors Hospital was assessed in this study.<p cl...