Endocrine Abstracts

IntroductionThe most common endocrine tumor is thyroid cancer. Follicular Thyroid Carcinoma (FTC) accounts for 5%–10% of all thyroid cancers. Patients with FTC frequently present with more advanced stage diseases and a higher occurrence of distant metastases because of the propensity of vascular invasion. FTC are mainly treated with surgery while radioactive iodine therapy (RAI) is main adjuvant therapy as per ATA guidelines. In many developing coun...

Introduction: Graves’ disease and Hashimoto’s thyroiditis are the two autoimmune spectrum of thyroid disease. Cases of conversion from hyperthyroidism to hypothyroidism have been reported but conversion from hypothyroidism to hyperthyroidism is very rare although reported. We report a case of hypothyroidism that converted to a hyperthyroid state needing treatment.Case report: A 36 years old female presented with a 3 months history of easy fatig...

Background: A four-tiered system is currently in place for weight management in the National Health Service (NHS). Tier 3 comprises specialist weight management services and aims for a clinically meaningful weight loss of ≥5%, as recommended by the National Institute for Health and Care Excellence (NICE). Within the Imperial Weight Centre (IWC), patients receive support from a multi-disciplinary team including endocrinologists, surgeons, dietitians, nurs...

Background: We present a 47-year-old female, who is known to have recurrent Graves’ disease, developed vasculitic skin lesions upon treatment with propylthiouracil (PTU).Case details: She was diagnosed with Graves’ disease in 2020 and was started on propylthiouracil as she could not tolerate carbimazole. Propylthiouracil was stopped after 18 months. Her thyrotoxicosis recurred after 6 months. Two months after p...

Background: We present a 47-year-old female, who is known to have recurrent Graves’ disease, developed vasculitic skin lesions upon treatment with propylthiouracil (PTU).Case details: She was diagnosed with Graves’ disease in 2020 and was started on propylthiouracil as she could not tolerate carbimazole. Propylthiouracil was stopped after 18 months. Her thyrotoxicosis recurred after 6 months. Two months after p...

Introduction: Primary hyperparathyroidism is associated with numerous cardiovascular complications including hypertension, left ventricular hypertrophy and calcification of cardiac valves. However NICE have not included cardiovascular complications as an indication of parathyroidectomy. This literature review will be focused on benefits of parathyroidectomy on cardiovascular complications of primary hyperparathyroidism.Methodology: Literature search done...

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Background: As per 2014 Endocrine Society guidelines, 131I-MIBG therapy is usually reserved for metastatic or unresectable disease in patients with pheochromocytoma / paraganglioma. In this series, we describe three patients effectively treated with primary 131I-MIBG therapy. The indications were primary neo-adjuvant therapy prior to surgery, or palliative.Case series: Case 1 – 18-year-old male with a 60 mm para-aortic paragang...

131I-metaiodobenzylguanide (MIBG) therapy, initially introduced in the 1980s, has emerged as a first-line to treatment of malignant phaeochromocytomas. Its other notable use has been in treating neuroblastomas occurring in childhood serving as an adjuvant prior to surgery or chemotherapy. An observed known late consequence of MIBG therapy is Primary ovarian failure (POI), characterised by menstrual irregularities over a period of 4 months associated with high Follicular stimul...

Background: Diabetic nephropathy (DN) is a micro-chronic diabetic complication brought on by changes in metabolism and hemodynamics. Inflammatory cytokines, generally IL-1β, IL-6 and IL-18 are linked in the development and advancement of DN. They act as pleiotropic polypeptides regulating inflammatory and immune responses through actions on cells. Fibrinogen is the liver-synthesized protein, with different functions and responses to both acute and chronic stimuli.AimThe a...