Endocrine Abstracts

Introduction: Urinary iodine concentration (UIC) and neonatal thyroid stimulating hormone (neoTSH) concentrations can reflect changes in iodine status and serve as a sensitive marker of iodine intake in pregnancy. As gestational diabetes mellitus (GDM) requires some diet modification, the study aimed to map the situation of iodine intake in women with GDM compared to healthy pregnant women and explore a relationship to thyroid function.Methods: In the tw...

The European Journal of Endocrinology Prize is a awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further inforamtion on the prize can be found on http://www.ese-hormones.org/prizes/eje.aspx. This year’s recipient is Professor Felix Beuschlein. The prize will be presented as part of the ECE 2013 opening ceremony ...

We have identified a signature that predicts response to androgen deprivation therapy in localized prostate cancer, and are now using this signature as a stratification variable on biomarker-driven clinical trials. Following up on the Stand-Up-To-Cancer sequencing findings we design a large umbrella trial which will personalize therapy based on actionable genomic alterations in metastatic castration-resistant prostate cancer.DOI: 10.1530/endoabs.42.IL12<...

The advent of new genetic techniques that allow for high-throughput sequencing in surgical tumour tissues and germline DNA has boosted progress in many fields of biomedical research. The technique has been proven to be particularly fruitful in the area of endocrine tumours with many new driver genes being identified over the last few years that are involved in cell growth but more importantly in hormonal autonomy. For the adrenal gland examples account for aldosterone and cort...

The advent of new genetic techniques that allow for high-throughput sequencing in surgical tumour tissues and germline DNA has boosted progress in many fields of biomedical research. The technique has been proven to be particularly fruitful in the area of endocrine tumours with many new driver genes being identified over the last few years that are involved in cell growth but more importantly in hormonal autonomy. For the adrenal gland examples account for aldosterone and cort...

The advent of new genetic techniques that allow for high-throughput sequencing in surgical tumour tissues and germline DNA has boosted progress in many fields of biomedical research. The technique has been proven to be particularly fruitful in the area of endocrine tumours with many new driver genes being identified over the last few years that are involved in cell growth but more importantly in hormonal autonomy. For the adrenal gland examples account for aldosterone and cort...

Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity and mortality. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and osteoporosis, which cannot be easily explained by aldosterone excess but would rather be associated with oversecretion of glucocorticoids. Over the last years, exome sequencing ha...

The advent of new genetic techniques that allow for high-throughput sequencing in surgical tumour tissues and germline DNA has boosted progress in many fields of biomedical research. The technique has been proven to be particularly fruitful in the area of endocrine tumours with many new driver genes being identified over the last few years that are involved in cell growth but more importantly in hormonal autonomy. Examples account for aldosterone producing adrenal adenomas, in...

Arterial hypertension is a major cardiovascular risk factor that affects between 10 and 40% of the population in industrialized countries. Primary aldosteronism (PA) is the most common form of secondary hypertension with an estimated prevalence of ~10% in referred patients and 4% in primary care. Despite its high prevalence until recently the underlying genetic and molecular basis of this common disease has remained largely obscure with the exception of the small subgroup of p...

Excessive autonomous aldosterone secretion by the adrenal gland, so called primary aldosteronism (PA), causes drug-resistant and often life threatening arterial hypertension accompanied by severe hypokalemia. Long-term consequences include increased risk for stroke, myocardial infarction and atrial fibrillation. PA is present in up to ~10% in referred patients and 7% in primary care, but as high as 20% in patients with resistant hypertension. The early detection of PA has clea...