Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

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2-4 November 2015, Edinburgh, UK Further information


Zoning in on adrenal tumours

ea0038s2.1 | Zoning in on adrenal tumours | SFEBES2015

Somatic mutations and adrenal remodelling in hyperaldosteronism

Brown Morris

Primary Aldosteronism (PA), due to a unilateral aldosterone-producing adenoma of the adrenal (APA), is the commonest curable cause of Hypertension, but the prospects for cure fall with age. APAs rarely increase in size, suggesting an origin much earlier than the development of resistant hypertension. Most APAs have gain-of-function somatic mutations which result in increased Ca2+ entry, and constitutive activation of aldosterone production. Women with larger APAs, a...

ea0038s2.2 | Zoning in on adrenal tumours | SFEBES2015

Advances in genetic causes of adrenal Cushing’s

Beuschlein Felix

The advent of new genetic techniques that allow for high-throughput sequencing in surgical tumour tissues and germline DNA has boosted progress in many fields of biomedical research. The technique has been proven to be particularly fruitful in the area of endocrine tumours with many new driver genes being identified over the last few years that are involved in cell growth but more importantly in hormonal autonomy. Examples account for aldosterone producing adrenal adenomas, in...

ea0038s2.3 | Zoning in on adrenal tumours | SFEBES2015

The new genetics of phaeochromocytoma

Gimenez-Roqueplo Anne-Paule

Paragangliomas and pheochromocytomas (PPGL) are neuroendocrine tumors with a very strong genetic component. A germline mutation in one of the 13 different susceptibility genes identified so far explains about 40% of all cases. Genetic testing, which is indicated in every patient, can be guided by the clinical presentation as well as by the secretory phenotype and by the immunohistochemical analysis of the tumors. The diagnosis of an inherited form drives clinical management an...