Endocrine Abstracts

The nutrient demands of cancer cannot be met by normal cell metabolism. Cancer cells undergo dramatic alteration of metabolic pathways in a process called reprogramming, characterized by increased nutrient uptake and re-purposing of these fuels for biosynthetic, bioenergetic or signaling pathways. Partitioning carbon sources toward growth and away from ATP production necessitates other means of generating energy for biosynthetic reactions. While much research has examined the ...

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Mitochondrial diseases are a common but challenging group of genetic conditions. The involvement of both the nuclear and mitochondrial genome means that the inheritance pattern is complicated. Mitochondrial diseases affect many different organs and may present to a variety of different physicians including endocrinologists. The treatment of mitochondrial diseases is challenging with no curative treatment available for the majority of patients. It is important to give symptomat...