Endocrine Abstracts

Introduction: The aim of this project was to review all adrenal masses ≥ 10 cm managed in our organisation over a 10-year period (2012-2022).Results: 20 adrenal masses ≥10 cm in maximal diameter were identified (range 10-32 cm, average 16.6 cm, 6 above 20 cm and one above 30 cm). Age at presentation was 17-80 y (mean 56.3 y, 50% F). Duration of symptoms: 1 day-18 months, mean 7.5 months with 6 presenting acutely. Follow-up period: 1 month-122...

Introduction: Type 1 Kidz is a project, facilitated by Investing in Children CiC, which offers regular group sessions to children and young people living with Type 1 Diabetes and their families across North East England. The aim is to support children and young people to share experiences and stories and learn together to improve their short and long term outcomes. This is supported by a Professional Steering Group.Methods: Monthly or quarterly group ses...

Introduction: Hyperthyroidism is a prevalent condition which affects approximately 2% of the female population and 0.2% of the male population in the UK. 75% of cases are caused by the auto-immune condition, Graves’ disease. Thyrotropin receptor antibodies (TRAb) are raised in 90% of patients with Graves’ disease and are commonly used to investigate the aetiology of thyrotoxicosis.Background: TRAb can be used to confirm Graves’ disease due...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise. It is associated with an increase in mortality and length of stay, independent of diagnosis and clinical variables. Despite this it is often inadequately investigated and poorly managed. As a number of endocrine conditions can cause hyponatraemia, endocrinologists often have the necessary clinical skills and expertis...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise (1). Proton pump inhibitors (PPI’s) are commonly prescribed in the UK, and the indication and duration of treatment is often not reviewed.Methods: A retrospective audit was performed of patients admitted to The Great Western Hospital (GWH) with a serum sodium of 127 mmol/l or less on admiss...

Introduction: Hyponatraemia is defined as serum sodium concentration <135 mmol/l. It is the most common electrolyte disorder encountered in clinical practise. It is associated with an increase in mortality and length of stay, independent of diagnosis and clinical variables. Despite this it is often inadequately investigated and poorly managed.Methods: A retrospective audit was performed of patients admitted to The Great Western Hospital (GWH) serum s...

Introduction: Hyponatraemia is common and associated with significant morbidity and mortality. However, it’s often not recognised as a serious diagnosis and therefore inadequately investigated and poorly managed. An audit of the management of patients admitted to The Great Western Hospital (GWH) with hyponatraemia confirmed these problems. A hyponatraemia guideline was produced in order to improve diagnosis, investigation, and management of patients with hyponatraemia.</p...

Introduction: The debate surrounding the most suitable pituitary provocation test in children is controversial. There is a perception that the gold standard insulin tolerance test (ITT) is ‘dangerous’ and that the glucagon stimulation test (GST) is ‘safer’ and a more tolerable alternative, particularly in younger children. There have been no reports in the literature comparing patient experiences of these tests.Aim: To examine the tol...

Case History: A 52 year old man presented in 2009 with a gradual loss of peripheral vision associated with headaches. Examination confirmed bi-temporal hemianopia. Further investigation revealed elevated prolactin levels and pituitary MRI showed evidence of large pituitary tumour. A diagnosis of macroprolactinoma was made and cabergoline was commenced. Given resistance to medical treatment, the patient required two surgical resections (2011 and 2013) and radical radiotherapy (...

The success of islet transplantation in the treatment of type 1 diabetes has been limited by the progressive decline in islet function and viability during isolation and post transplantation. The aims of the current study were to investigate the capacity of a multifunctional progenitor cell type, mesenchymal stromal cells (MSCs), to improve islet insulin secretory function and viability after exposure to transplantation relevant stressors. Mouse islets were cultured with low (...