Endocrine Abstracts

Endocr Relat Cancer August 1, 2015 22 481–504. DOI: 10.1530/ERC-14-0546...

A 62-year-old Asian British female presented with increasing tiredness. She had multiple co-morbidities and was prescribed steroid inhalers for suspected asthma. Her type 2 diabetes mellitus, previously well controlled on metformin, had worsened over a short period of time (48 to 85 mmol/mol). On examination, she was obese (weight 82 kg, BMI 43 kg/m2), hypertensive (155/78 mmHg); rest of the examination was unremarkable. The blood test revealed undetectable cortisol...

Hypoglycaemia is a one of the commonest presentation of an ill child. Hyponatraemia during illness is mostly presumed to be related to syndrome of inappropriate anti diuretic hormone secretion (SIADH). We would like to present an interesting case of hypoglycaemia and hyponatraemia.A four-year-old boy presented with a two-day history of intermittent fever, vacant episodes, and seizures. He was noted to be hypoglycaemic with laboratory glucose of 1.2 mmol/...

Introduction: Two patients admitted for evaluation of a hypercalcemia and hypothyroidism whose etiologic diagnosis showed itself unusual.Case no. 1: A 45 years old man allowed for disorders of consciousness, vomitings and headaches, biology showed a hypercalcemia, a hypophosphoraemia, hyperPTH. The imaging revealed parathyroidal adenoma with a compressive prolactinema. Pet Scan-FDG showed a metabolic activity of the thymic cavity with a necrotic aspect, ...

Introduction: Immune dysregulation is a feature of Cushing’s syndrome (CS). We report a case of CS that presented with rapidly developing cutaneous Kaposi’s sarcoma (KS).Case description: A previously well 59-year-old heterosexual man presented with a two-month history of proximal muscle weakness, recurrent mouth ulcers, and purplish skin lesions. He had a background history of hypertension. Skin biopsies were compatible with KS. History of pas...

A 42-year-old female had extensive neurological investigations (normal MRI brain, EEG, NCS). A low CSF glucose triggered endocrine referral. She had a history of ill health/fatigue since 19 years when she had a viral illness with seizure-like episode and transient wheelchair dependance, with no formal diagnosis made. She had recurrent symptoms including fatigue, myalgia and weakness, with some relation to hunger and fasting.Physical examination revealed ...

Background: Sepsis is hallmarked by an immediate and sustained decrease in total-, HDL-, and LDL- cholesterol, associated with poor outcome and suggested to be a potential contributor to adrenal failure and muscle weakness in the critically ill. Although the underlying mechanisms are unclear, this sepsis-induced hypocholesterolemia has been postulated to be due to an increased conversion of cholesterol to cortisol. We hypothesized that hydrocortisone (HC) trea...

Purpose: Sepsis is hallmarked by high circulating glucocorticoids in face of low plasma adrenocorticotropic hormone (ACTH) (1). At the hypothalamic-pituitary level, ongoing stress-induced corticotropin-releasing hormone- (CRH) and arginine vasopressin- (AVP) driven expression of the ACTH-precursor POMC coincides with impaired proprotein convertase 1 (PC1/3)-mediated processing into ACTH, with ultimately leaching of unprocessed POMC into the circulation (2). Despite uncertainty...

Aim: For several decades, transient hypothyroxinemia of prematurity is topic of debate. The pathophysiology is incompletely understood and consensus on the therapeutic approach is lacking. This study aimed to obtain more insight in the pathogenesis by studying trends in thyroid hormone levels during the first week of life.Methods: This single-center prospective observational study studied plasma levels of total and free T4, total T3, TSH and TBG in cord ...

Introduction: Patients in need of an intensive care unit (ICU) treatment due to severe diseases often develop the non-thyroidal illness syndrome (NTI). These critically ill patients present with low thyroxine (T4), low 3,3’,5-triiodothyronine (T3) and elevated reverse T3 (rT3) serum concentrations while TSH and 3,3’-diiodothyronine (3,3’-T2) concentrations remain unaffected. To further elucidate the underlying changes ...