Endocrine Abstracts

Background: Colorectal cancer is the world’s third most common cancer. The prognosis is mainly determined by the stage of the tumor, but several other factors related to the patient, such as co-morbidities, may also have an impact on the disease course. The aim of our study was to assess the prognostic value of diabetes and obesity in colorectal cancer.Methods: We conducted a retrospective study including patients diagnosed with primary colon or rec...

Background: Malnutrition and weight loss are well-recognized complications of Crohn disease (CD), however nutritional routine assessment is not commonly performed, resulting in under-detection and under-treatment of both malnutrition and nutrient deficiencies. In fact, a number of nutrition screening tools are available including the Nutritional Risk Index (NRI).Aim: The aim of this study was to investigate the prevalence and the associated factors of ma...

Introduction: Congenital hypopituitarism is considered a study model to understand the mechanisms of development and the physiological functioning specific to the pituitary gland. Its exact prevalence is challenging to establish. In this report, we present the experience of the endocrinology department at Hedi Chaker University Hospital in Sfax regarding the diagnosis and management of patients with antehypopituitarism associated with growth hormone deficiency (GHD).<p cla...

IntroductionAdrenocortical carcinoma is a rare neoplasm with local development, rarely metastatic in the spine. We report a case of metastatic dorsal spinal cord compression due to adrenocortical carcinoma.ObservationA 38-year-old lady with no notable medical history, complained of generalised weakness, severe abdominal pain and spasms. Abdominal computed tomography showed a large right adrenal renal mass mea...

Background: There is wide variation in the reported rate of acute adrenal insufficiency (AI) related adverse events (sick day episodes and adrenal crises) between centres.Objective: Evaluate the level of consensus on the criteria that should be considered ‘essential’ for defining and managing adverse events associated with acute AI in children.Methods: Active users of the International Congenital Adrenal Hyperplasia &...

Background: Women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency have a poor Quality of Life (QoL) compared to the general population and are less satisfied with their body appearance. Data indicates that psychosocial determinants such as good professional and general support could be associated with an improved QoL. Since there is only little data available that has been deduced from samples of small size this effect should be further examined....

Context: Congenital adrenal hyperplasia (CAH) is caused by 21-hydroxylase deficiency in 95% of the cases. This leads to accumulation of steroid precursors prior to the enzymatic block and increased adrenal androgen production; accordingly serum concentrations of 17-hydroxyprogesterone (17OHP), androstenedione and testosterone are elevated in affected patients.Objective: To analyse the effect of 17OHP, androstenedione and testosterone on aldosterone-media...

Infertility is a serious problem in female as well in male CAH patients. The most important cause of male infertility in CAH patients is the presence of testicular adrenal rest tumors (TART). The reported prevalence in adult CAH patients is up to 96%. TART have no malignant features but because of their typical localization near the mediastinum testis, longstanding compression of the seminiferous tubules may lead to obstructive azoospermia and irreversible damage of testicular...

Introduction: The interaction between diabetes and obstructive sleep apnea syndrome (OSAS) is little recognized. We hypothesized that diabetes and OSAS act synergistically to increase the risk of right ventricular systolic dysfunction and that treatment of OSAS would improve right ventricular (RV) systolic function in patients with diabetes plus OSAS.Methods: Cross-sectional study including 100 patients with severe OSAS, 49 of whom have associated diabet...

Objective: To assess the predictive factors for the occurrence of urinary dysfunction (UD) in patients with diabetes mellitus (DM).Patients and Methods: Case-control study comparing two groups of patients suffering from DM: G1 (n=159) with UD vs G2 (n=41) without UD.Results: G1 patients were older than G2 patients (59.7&pm;10.3 vs 58&pm;12 years) with no significant difference in gender. The duration of diabetes w...