Endocrine Abstracts

Introduction: Exosomes are nanoparticles containing bioactive molecules reflecting individual physiological status, regulating metabolism, and repairing damaged tissues. Exosomes are extracellular vesicles with nano-sized features (30-150 nm) involved in cell-to-cell communication and maintaining homeostasis. The function of exosomes is different according to their cargo and they can contain lipids, proteins and nucleic acids. Exosomes originating from mammalian cells as well ...

M Kawata, Kyoto Prefectural University of Medicine, Kyoto, Japan AbstractMitsuhiro Kawata is Professor of Anatomy and Neurobiology at Kyoto Prefectural University of Medicine. He received both an MD and a PhD from Kyoto Prefectural University of Medicine and has spent his scientific career at the Rockefeller University and University of Edinburgh. His research interests over time lie in the search for the mechanism of ...

Sexual difference of behavior is primarily attributed by structural sexual dimorphism in the nervous system. Recently, we found two sexually dimorphic systems in the central nervous system: 1) newly identified hypothalamic nucleus expressing estrogen receptor (ER) alpha and 2) gastrin releasing peptide (GRP) system in the spinal cord.Sagittalis nucleus of the hypothalamus (SGN), situated between the arcuate nucleus and ventromedial nucleus, is larger in ...

Objective: Poor sleep quality is a prevalent health problem among patients with diabetes. Metabolic syndrome (MetS) is common in type 2 diabetic patients, and associated with morbidity and mortality. We aimed to investigate sleep quality among type 2 diabetes patients according to their metabolic syndrome status.Participants: This was an analysis of data collected from 189 adult type 2 diabetic patients.Methods: The patients were d...

Growth hormone (GH) is an important factor involved in the regulation of multiple biological functions. Although the influence of GH is widespread throughout several organs and tissues, the effects of GH on brain functions, such as those related to reproductive functions, are still elusive. GH deficiency or resistance can be related to late puberty onset, lack of sexual maturation and infertility. In contrast, GH therapy can accelerate puberty onset or be used to increase preg...

It is well established that the kisspeptins are the main activators of GnRH neurons and therefore essential for the onset of puberty and reproduction. Previous studies have suggested that kisspeptin neurons are possibly major targets of pro-inflammatory cytokines to regulate reproduction. SOCS (suppressor of cytokine signaling) are proteins that regulate, as it says, cytokines. They inhibit the transduction of intracellular effects caused by those molecules, once that cytokine...

Introduction: Under-nutrition is a greater risk factor for low productivity andpoor health as diabetes1. In Benin 11.9% of males and 9.5% of females were underweight2 and 5.3% of the population have diabetes3. There is no data available on underweight among diabetic in Benin.The aim of this study is to determine the prevalence of underweight among diabetic and the associated factors.Method: It was a...