Endocrine Abstracts

Background: Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Hypertension, CVD, and metabolic trouble.Aim and objective: The aim of this study is to investigate whether there was a relationship between m...

Background: Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Diabetes, CVD, and metabolic trouble.Aim and objective: The aim of this study is to investigate whether there was a relationship between morni...

Aims: Epidemiological studies have demonstrated that Indian babies born to mothers with gestational diabetes mellitus (GDM) have adverse metabolic profiles. The anthropometric and metabolic profiles in children of women with and without GDM were compared at age 5 years.Methods: Children born to mothers with GDM (CGDM) and without GDM (WGDM) were included in this prospective study. We examined maternal gestational BMI, GD...

Background: Familial Diabetes Insipidus is a very rare entity and can have either neurohypophyseal (FNDI) or nephrogenic forms with different transmission patterns. FNDI accounts for less than 5% of the 1:25 000 cases of DI diagnosed in UK. It is usually an autosomal dominant disorder caused by mutations in AVP (arginine vasopressin) gene, which regulates the vasopressin hormone synthesis; its signs and symptoms of polyuria & polydipsia usually become apparent in childhood...

With increasing prevalence of type 2 diabetes in India, macrovascular complications are also on the rise. We undertook a retrospective study to evaluate the metabolic profile of type 2 diabetes patients undergoing coronary artery bypass grafting (CABG) at our centre. Clinical data on 672 consecutive patients undergoing elective CABG was included from the hospital data base after informed consent and ethics committee approval. Mean age of the patients was 49.7±9.5 years; 5...

A 25 year old gentleman was referred to the endocrine clinic for evaluation of abnormal thyroid function tests. He reported symptoms of diffuse abdominal pain associated with loose stool up to six times a day with urgency, frequency and tenesmus. These symptoms had been present since childhood, becoming increasingly troublesome over the preceding two years. He also reported symptoms of tiredness, palpitations and sweating episodes. Thyroid function tests were abnormal. TSH was...

Background: Vitamin D (25(OH)D) deficiency is a global public health issue. An association with obesity and diabetes has been described in adult and paediatric populations. This study investigates the prevalence of 25(OH)D deficiency and its correlates in population of Emirati children and adolescents attending a large diabetes centre in the United Arab Emirates.Methods: Participants aged 4-19 years were selected based on diabetes status [type 1 diabetes...

Women with polycystic ovary syndrome (PCOS) have twice the risk for metabolic syndrome (MetS) compared to women from the general population. Mothers and sisters of affected women also have an increased prevalence of MetS. We undertook this study to evaluate whether these abnormalities are also present in brothers’ of affected women.Design and setting: A total of 59 brothers (age ≥18 and ≤40 years) of women with PCOS and 59 healthy men (o...

Hyperglycaemia is common in patients (~65%) when they are admitted to hospital with ACS. It is recognised to be one of the important prognostic indicators for all-cause mortality in patients who present with ACS, regardless of pre-existing diabetes1. NICE guidelines recommend to keep blood glucose (BG) levels below 11 mmol/l2 and offer all people with hyperglycaemia after ACS (without known diabetes) for HbA1c 3 check before discharge. We were interested to see whether we foll...

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...