Searchable abstracts of presentations at key conferences in endocrinology

ea0031p191 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Novel inositol pyrophosphate and insulin sensitivity in response to muscle contraction in glucose intolerant humans

Naufahu Jane , Watt Peter , Mellish Louise , Elliott Bradley , Kerekgyarto Anna , Mackenzie Richard

Peripheral insulin resistance is a major defect associated with glucose intolerance and type two diabetes. Yet the mechanism(s) responsible for this defect remain to be determined. Inositol pyrophosphate (IP7) is formed via the enzyme IP6K1 from IP6. The inhibition of Akt, and the potential decrease in insulin signalling, through the binding of IP7 to the Akt PH domain represents an exciting research area.Firstly, we will characterise this mechanism in h...

ea0031pl3biog | Society for Endocrinology European Medal Lecture | SFEBES2013

Society for Endocrinology European Medal Lecture

Spada Anna

Anna Spada is currently Full Professor at the School of Medice, University of Milan. Her main research interests are on signal transduction in pituitary cells, pathogenesis of pituitary tumors, genotype/phenotype relationships in acromegalic patients with gsp mutations, tissue specific GNAS1 gene imprinting, molecular mechanisms of resistance to hormone action, activating and inactivating mutations of GNAS1 in endocrine disorders, polymorphic variants of somatostatin receptor ...

ea0074ncc48 | Highlighted Cases | SFENCC2021

The pragmatic use of corticosteroids in the diagnosis and treatment of non-PTH driven hypercalcaemia

Yousif Yasear Zainab Akram , Ijaz Nadia , Gittoes Neil , Sanders Anna , Pang Terence

A 65-year-old gentleman was referred by his GP because of acute kidney injury and hypercalcaemia, which was associated with low levels of parathyroid hormone. He had been fit and well and was on no regular medications. Whilst his hypercalcaemia was partly correctible with saline rehydration, cautious use of bisphosphonates and cinacalcet were not effective in preventing rebound, and his nephropathy persisted. Curiously, he had longstanding low plasma alkaline phosphatase, but had normal denti...

ea0081ep1093 | Thyroid | ECE2022

Successful treatment of Graves’ disease with high dose iodine-131, without subsequent hypothyroidism: a case report

Brodovskaia Anna

Background: Radioiodine is an effective treatment for Graves’ hyperthyroidism. In most cases this therapy renders the patient completely hypothyroid. As a consequence they will require lifelong thyroid replacement therapy. Now it is controversial whether radioiodine should be given in a sufficient dose to induce hypothyroidism or a lower dose in an attempt to achieve a euthyroid state. Case Report: A 71-year-old woman with a 30 years history of Grav...

ea0050cmw3.6 | Workshop 3: How do I. . . (1) | SFEBES2017

How do I . . . . implement patient safety alerts for adrenal insufficiency across my institution

Mitchell Anna

Steroid-dependent individuals, in particular those with primary adrenal insufficiency, are a vulnerable patient group. They are prone to acute adrenal crisis which is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency, acute adrenal crisis has a frequency of 6–8 per 100 patient-years. Unfortunately, delays in diagnosis and management are common, constituting an avoidable source of patien...

ea0050cmw5.1 | Workshop 5: How do I. . . (2) | SFEBES2017

How do I follow up a patient with an indeterminate non-functioning adrenal nodule?

Crown Anna

Incidentally discovered adrenal nodules are an increasingly common reason for referral into the endocrine clinic. Assessment includes a hormonal work-up to look for endocrine function, and reviewing the size and radiological characteristics of the lesion. Some nodules have benign radiological features (less than 10 HU on an unenhanced CT scan), whilst others are radiologically indeterminate (more than 10 HU). We worry about missing a malignant process. The research data and in...

ea0050cmw3.6 | Workshop 3: How do I. . . (1) | SFEBES2017

How do I . . . . implement patient safety alerts for adrenal insufficiency across my institution

Mitchell Anna

Steroid-dependent individuals, in particular those with primary adrenal insufficiency, are a vulnerable patient group. They are prone to acute adrenal crisis which is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency, acute adrenal crisis has a frequency of 6–8 per 100 patient-years. Unfortunately, delays in diagnosis and management are common, constituting an avoidable source of patien...

ea0050cmw5.1 | Workshop 5: How do I. . . (2) | SFEBES2017

How do I follow up a patient with an indeterminate non-functioning adrenal nodule?

Crown Anna

Incidentally discovered adrenal nodules are an increasingly common reason for referral into the endocrine clinic. Assessment includes a hormonal work-up to look for endocrine function, and reviewing the size and radiological characteristics of the lesion. Some nodules have benign radiological features (less than 10 HU on an unenhanced CT scan), whilst others are radiologically indeterminate (more than 10 HU). We worry about missing a malignant process. The research data and in...

ea0090n1.3 | Acromegaly: Technologies and therapies | ECE2023

Case Study: Complex case of acromegaly

Hawkins Anna

Presenting the complex journey of a 36 year old lady who following over 2 years of symptoms was found to have raised IGF1 and prolactin. She had microscopic transsphenoidal resection of pituitary adenoma. This was followed by different medical therapies and Gamma knife radiotherapy. She was also referred to many other specialists for Acromegaly related conditions and surveillance. The pathway to diagnosis can be full of barriers and may take many years for a patient to travel ...

ea0044cmw4.5 | Workshop 4: How do I manage…(Supported by Endocrinology, Diabetes & Metabolism Case Reports) | SFEBES2016

How do I manage hypothalamic amenorrhoea?

Crown Anna

‘Functional’ hypothalamic amenorrhoea (FHA) is a common cause of secondary amenorrhoea. A focused history should include a full menstrual history (including hormonal contraception); diet, weight and exercise (including any eating disorder); any significant stressors; the woman’s current situation in relation to contraception and fertility plans; a personal or family history of a lack of sense of smell (suggesting Kallmann syndrome); and any family history of del...