Endocrine Abstracts

The endocrine system is crucial in spermatogenesis and any hormonal alterations may affect fertility. Prolactin (Prl) plays a role in male reproduction, as evidenced by presence of prolactin receptors on various testicular cells. However, the exact mechanism and physiological role of testicular prolactin receptor during spermatogenesis remains elusive. Clinical conditions such as hyper- and hypo-prolactinemia are known to have deleterious effects on male reproduction. The aim ...

Estrogen, through its receptors, plays an important role in regulation of spermatogenesis. The importance of estrogen is highlighted with the reports that environmental estrogens have deleterious effects on spermatogenesis and have been associated with declining sperm counts in men. Although estrogen receptors (ERα and ERβ) have been localised in the seminiferous epithelium; their precise roles are yet unclear as in vivo estradiol treatment would signal thro...