Endocrine Abstracts

Background: Expected progression free survival (PFS) for patients with grade 3 well-differentiated neuroendocrine tumors (WD NET) treated with peptide receptor radionuclide therapy (PRRT) is approximately 9 months, and objective response rate (ORR) is 35%. Response rate to single agent immune checkpoint inhibitors (ICI) for patients with G1-3 NET is <15%. Delivery of targeted radiation using PRRT may potentiate the anti-tumor immune response. The purpose of this study is t...

Materials and methods: We studied 30 MO patients with OSA without Continuous Positive Airway Pressure (CPAP) treatment, before and one year after surgery. All patients underwent overnight conventional polisomnography (CE-Series Compumedics, Victoria, Australia). Sleeve gastrectomy or Roux-en-Y gastric bypass were performed according to the local protocol. To asses AS, augmentation index adjusted for heart rate (IAx@75) was obtained by applanation tonometry (Sphygmocor&#17...

Introduction: HO1 is a new adipokine with a protective role against cellular stress and hypoxia1. MO presents with high low grade inflammation (LGI)2 and high circulating levels or adipose tissue expression of HO13. The effect of bariatric surgery on HO1 and its relationship with OSA and LGI has not yet been studied.Methods: We studied 66 MO patients before and 1 year after BS. All of them presented OSA without Continuous...

Background: The clinical heterogeneity of G2 and G3 well-differentiated GEP-NENs make it difficult to choose an effective treatment plan, highlighting the need of molecular imaging in the treatment of NETs patients. It has been suggested that a dual-tracer 68Ga-DOTATATE/18F-FDG grading scoring system could be a useful imaging biomarker. This pilot study aims to validate the prior observation from Chan et al. (BJC 2022) of variability in NETPET scores in G2-G3 WD GEP NENs and a...

The melanocortin-2-receptor (MC(2) receptor), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC(2) receptor in adrenal physiology is exemplified by the condition familial glucocorticoid deficiency (FGD), a potentially fatal disease characterised by isolated cortisol deficiency. MC(2) receptor mutations cause ~25% of cases. The discovery of a MC(2) receptor accessory protein MRAP, mutations of which account...

The melanocortin-2-receptor (MC(2) receptor), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC(2) receptor in adrenal physiology is exemplified by the condition familial glucocorticoid deficiency (FGD), a potentially fatal disease characterised by isolated cortisol deficiency. MC(2) receptor mutations cause ~25% of cases. The discovery of a MC(2) receptor accessory protein MRAP, mutations of which account...

The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whilst MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.The melanocortin receptor accessory proteins, MRAP and its paralogue MRAP2, are small single-pass transmembrane proteins tha...

Overt hypothyroidism, diagnosed and treated with L-thyroxine pre-pregnancy, affects 1% of pregnancies. Untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes, and even when partially treated the risks of miscarriage and prematurity remain elevated compared to euthyroidism. With increased understanding of the normal physiological changes to thyroid function during pregnancy, there should be a predictive approach to thyroxine ...

Background: Patients with metastatic carcinoid disease confer a risk for carcinoid syndrome, characterized by hemodynamic instability and syncope. While the physiologic mechanisms linking carcinoid tumor metastases to impaired blood pressure regulation are not well understood, this may be attributed to changes in autonomic function, which is a key regulator of blood pressure. We hypothesize that metastatic carcinoid disease induces autonomic dysfunction. To test this, we longi...

Background: Neuroendocrine tumors that release prostaglandins and biogenic amines that can impact cardiac function. In consequence, patients with carcinoid liver metastases are at risk for carcinoid heart disease. This is primarily characterized by fibrosis in the heart that leads to plaques on the valvular cusps, leaflets and walls of the atrium and ventricles leading to a thickened right heart with regurgitation. Interestingly, 50-80% of patients with carcinoid heart disease...