Endocrine Abstracts

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...

Hypoparathyroidism is an endocrine disease caused by insufficient levels of parathyroid hormone (PTH). Individuals with chronic hypoparathyroidism managed with conventional therapy (active vitamin D and calcium) are at increased risk for renal complications and declines in renal function. In clinical trials, palopegteriparatide treatment enabled independence from conventional therapy (no active vitamin D and ≤600 mg/day elemental calcium) and maintained serum biochemistr...

Background: The transition from paediatric to adult care can be challenging for patients with Type 1 diabetes. Poor contiuity of care provided by the diabetes team may worsen an already difficult time for these patients. Good transition of care is vital to minimise the risk of worsening patient outcomes. In 2016, two patients failed to transition from paediatric to adult diabetes care and subsequently received no adult appointment. This breakdown of continuity of care was a re...

ObjectiveTo assess the results of bilateral adrenalectomy and further assess the relevance of Nelson's syndrome as a complication of bilateral adrenalectomy.Patients33 patients treated by bilateral adrenalectomy at the Hammersmith Hospital were identified (earliest operation performed in 1958). Although all bilateral adrenalectomies in recent years were included, it was not possible to confirm that all bilate...

Introduction: Recommended starting insulin doses in CYP with newly diagnosed type 1 diabetes vary widely from 0.3 to 1.0 U/kg/day. However, there is no study for rate of change of insulin dose in first few months of initiating insulin.Aim: Retrospective review of insulin total daily dose at diagnosis, hospital discharge, and at first clinic, documenting changes in % basal insulin with time, considering any impact of insulin treatment on body weight and H...

A 69-year-old non-diabetic woman presented with 1 month of recurrent drowsiness and confusion secondary to hypoglycaemia, nocturnal and on fasting. On admission her CBG was 2.6 mmol/l, confirmed venously. Her history was of a large solitary fibrous tumour (SFT) of the chest wall first resected in 2011 with recurrent relapses requiring surgery in 2016 and 2017. Histology showed typical features of SFT. Despite palliative chemo-radiotherapy for a further relapses, there was prog...

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis of probable viral origin. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain largely unclear.Methods: A retrospective analysis of patients with SAT at the University Hospital of Brussels from 2001-2020 w...

Introduction: Incidental indeterminate adrenal nodules discovered on imaging in patients under the care of University Hospitals of Derby and Burton Foundation Trust are discussed in Urology MDT. MDT cases were reviewed for a 12 month period before an endocrinologist joined the MDT in January 2018 and 12 months afterwards, to review the compliance of local practice with European Society of Endocrinology (ESE) Guidelines for the management of adrenal incidentalomas.<p class=...

Background: Pulmonary carcinoids (PC) are rare neuroendocrine tumors (NETs). The course of PCs is considered to be indolent, but patients with advanced disease have low survival rates and their treatment options are limited. As PCs are under-represented in trials, therapeutic decisions are based on evidence extrapolated from other types of NETS. Capecitabine-Temozolamide (CAPTEM) has demonstrated significant efficacy in pancreatic NETs. However, its role in PCs is still unexpl...

We have previously shown that the ACTH precursor, POMC, is present in human plasma and is the predominant secreted POMC peptide. This suggests that POMC processing is incomplete in neuroendocrine cells and regulation of the post-translational cleavage pathway is important in controlling secretion of ACTH. We have therefore analysed the dynamics of POMC processing in both AtT20 pituitary adenoma cells and primary rat pituitary cells. In both cases, large quantities of POMC, as ...