Endocrine Abstracts

Primary aldosteronism (PA) is a form of endocrine hypertension characterized by autonomous aldosterone secretion. Aldosterone-producing adenomas (APAs) are a significant cause of unilateral PA, where aldosterone overproduction is driven by a somatic mutation in an ion pump or channel. Multiple studies have shown that mutations in the KCNJ5 gene are the most prevalent in PA patients suffering from the unilateral subtype, and unilateral laparoscopic total adrenalectomy ...

Turner syndrome (TS) is the most common chromosomal anomaly in females and its occurrence is about 1:4000 live births. This is the only monomer disease that humans can survive (1). It is characterized by the presence of one X chromosome and a partial or complete loss of the second X chromosome. Clinical features of TS can vary, mainly classified into Growth failure, gonadal insufficiency, cardiovascular diseases, or learning disabilities. Short stature is the only phenotypic a...

Introduction: Hyponatremia in patients with pituitary tumours are common due to many reasons including secondary hypoadrenalism and secondary hypothyroidism. When these causes are treated with the background of hyponatremia, serum sodium should be regularly monitored as it could get corrected too rapidly leading to ODS.Case report: 34 Year old patient presented to a tertiary care hospital with headache. His MRI brain revealed a large suprasellar lesion s...

Pituitary apoplexy caused by pure infarction is rare. Here we present three cases of pituitary macroadenoma infarction following hypotension.1. An 84 year old gentleman had a 2 × 2 cm pituitary macroadenoma causing chiasmal compression and a bitemporal hemianopia. He had panhypopituitarism and was on prednisolone, thyroxine and testosterone replacement. Before surgical intervention of the macroadenoma, he fell and broke his humerus, which requi...

Background: Primary aldosteronism (PA) is the most frequent cause of endocrine hypertension associated with excess aldosterone production from one or both adrenal glands. Somatic or germline mutations in the KCNJ5 potassium channel cause an imbalance in intracellular ion homeostasis. This ultimately drives aldosterone overproduction in some sporadic forms of PA and a familial form of the disease (familial hyperaldosteronism type 3). Our objective was to identify small molecule...