Endocrine Abstracts

Temozolomide, an alkylating agent used in malignant gliomas, has been recently used too in the treatment of aggressive pituitary tumors. To date, two cases of Nelson’s syndrome has successfully treated with 5 days of 28-day cycle, but the follow-up has been shorter than 12 months. We reported the third patient with Nelson’s syndrome treated with temozolomide, who after an initial goal response to three 300 mg 5 days of 28-day cycles shown a clinical and biochemical (...

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...

Introduction: Sleep disordered breathing (SDB) promotes structural myocardial changes and can trigger cardiac arrhythmias. Acromegalic patients have high prevalence of SDB and GH–IGF1 excess is related to a specific cardiomyopathy characterized by concentric cardiac hypertrophy and diastolic dysfunction. The aim of this study was to assess the relationship between SDB and cardiac dysfunction on acromegalic patients.Material and methods: Observationa...

Background: There is an increasing interest to find specific prognostic markers of the aggressive behaviour of some pituitary adenomas (PA). The most studied markers have been the immunohistochemical staining for Ki-67 and p53. The aim of this study was to evaluate the relevance as possible prognostic markers of growth factors (IGF1R), angiogenic factors (VEGF and his receptor) and new genes (PTTG) versus the immunohistochemical expression of Ki-67 and p53 in PA.<p class="...

Context: The determination of human chorionic gonadotropin (hCG) in cerebrospinal fluid (CSF) is useful for the differential diagnosis of suprasellar lesions. However, the concentrations that prove diagnostic for neurohypophyseal germinoma have not been well defined. In addition, the immunoassays used for such determination are the same as those applied in serum, and few studies have been performed regarding the validation of such techniques in CSF.Objec...

Introduction: Salivary testosterone (Sal-T) reflects the plasma free testosterone fraction that can flow passively through the salivary glands and appears to be a strong correlation with the Calculated free testosterone (CFT) in both eugonadal and hypogonadal men. Since the collection of saliva is simple, noninvasive and inexpensive, the Sal-T is a promising tool for the screening of hypogonadism. Despite the initial interest that Sal-T has aroused, new clinical studies are ne...

Pituitary adenomas are heterogeneous, rare tumors, which hinders analysis of large numbers of cases with common approaches. To overcome this, a multicenter, clinical-basic strategy was proposed aimed at enhancing the tools to diagnose and manage pituitary tumors by combining clinical/pathological/molecular information. This initiative was developed by the Sociedad Andaluza de Endocrinología y Nutrición, and further endorsed by the Sociedad Española de Endocrinol...

Introduction: Hyponatremia is the most common electrolyte disorder in hospitalized patients. SIADH is characterized by euvolemic hyponatremia with sodium and urine osmolality inappropriately high. The selective antagonist of the vasopressin V2 receptor (tolvaptan) helps to eliminate water free of solute (aquaresis), being effective in treating this condition.Objetive: Evaluate the efficacy and safety of tolvaptan in the treatment of SIADH.<p class="a...