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ea0029p1611 | Thyroid (non-cancer) | ICEECE2012

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

Agretti P. , Ferrarini E. , De Marco G. , Dimida A. , Molinaro A. , Niccolai F. , Pinchera A. , Vitti P. , Tonacchera M.

Background: Nonautoimmune subclinical hypothyroidism is characterized by elevated serum levels of TSH in the presence of normal thyroid hormone levels and absence of anti-thyroid antibodies. As a result of a genomic-wide study, a strong association between three polymorphic variants in exon 1 of human phosphodiesterase 8B (PDE8B) gene (rs4704397, rs6885099 e rs2046045) and serum levels of TSH has been recently reported. The aim of the present study was to evaluate the frequenc...

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ea0029p1612 | Thyroid (non-cancer) | ICEECE2012

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

Agretti P. , Ferrarini E. , Rago T. , Candelieri A. , De Marco G. , Dimida A. , Niccolai F. , Molinaro A. , Di Coscio G. , Pinchera A. , Vitti P. , Tonacchera M.

Objective: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that pair with target messengers regulating gene expression. They are involved in biological processes including development, organogenesis, tissue differentiation, cell cycle and metabolism. Changes in miRNA levels occur in human cancers, including thyroid cancer. Fine needle aspiration (FNA) with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytologic diagnos...

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ea0014p274 | (1) | ECE2007

The endocrine disruptor DDT appears to be an uncompetitive inverse agonist for activating TSHr mutants, FSH receptor and LH receptor

Montanelli Lucia , Ferrarini Eleonora , Dimida Antonio , Rossi Mario , Agretti Patrizia , Giorgi Franco , Corsini Giovanni Umberto , Pinchera Aldo , Vitti Paolo , Maggio Roberto , Tonacchera Massimo

The insecticide DDT has been shown to inhibit both the basal and the TSH stimulated accumulation of cAMP in CHO stably transfected with the TSHr (CHO-TSHr). Aim of this study was to evaluate whether the DDT has a similar effect on cells transfected with TSHr mutants displaying a high level of constitutive activity. In addition we investigate the effect of DDT on cells transfected with wtFSHr and wtLHr which share a high degree of amino-acid homology sequence with wtTSHr. In co...

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ea0011p884 | Thyroid | ECE2006

Gene expression profile in orbital fibroblasts from a tao patient before and after adipocytic differentiation

Agretti P , de Marco G , Ferrarini E , Dimida A , Sansone D , Banco M , de Servi M , Lisi S , Marcocci C , de Marinò G , Vitti P , Pinchera A , Tonacchera M

Thyroid associated ophthalmopathy (TAO) is a chronic autoimmune disorder characterized by an increased volume of the adipose/connective tissue in the human orbit. Fibroblasts from the connective orbital tissue are able to differentiate into mature adipocytes if grown in particular culture conditions. Aim of the present study was to determine the gene expression profile of orbital fibroblasts after adipocytic differentiation. Fibroblasts in primary culture were obtained from or...

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ea0011p688 | Reproduction | ECE2006

Identification and functional study of a new FSH receptor gene mutation in women affected by polycystic ovary syndrome (PCOS)

Ferrarini E , Jr Orio F , Palomba S , Cascella T , Dimida A , di Biase S , Labella D , Agretti P , de Marco G , Gianetti E , Vitti P , Colao A , Lombardi G , Pucci E , Pinchera A , Tonacchera M

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women, affecting up to 10% of women in reproductive age. The evidence of polycystic ovaries at ultrasonography has been recently considered as a further criteria to diagnose PCOS. In order to determine whether FSH receptor gene affects hormonal and/or metabolic parameters of PCOS women the presence of FSH receptor gene mutations was investigated. Forthy women aged between 18 and 40 years with poly...

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Endocrine Abstracts

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

The endocrine disruptor DDT appears to be an uncompetitive inverse agonist for activating TSHr mutants, FSH receptor and LH receptor

Gene expression profile in orbital fibroblasts from a tao patient before and after adipocytic differentiation

Identification and functional study of a new FSH receptor gene mutation in women affected by polycystic ovary syndrome (PCOS)

BiosciAbstracts