Endocrine Abstracts

Aim: To evaluate sleep architecture of patients with Cushing’s disease (CD) and to explore whether agouti-related peptide (AgRP) leptin, and interleukin-6 (IL-6) play a permissive role in sleep alterations.Methods: We performed polysomnography on 26 patients with active CD and age 26 age- and sex-matched control subjects. Blood samples were obtained from all participants for the analyses of AgRP, leptin, and IL-6. The laboratory and sleep-related pa...

Aim: To investigate the volumetric changes in cortical and subcortical deep gray matter (GM) structures and cognitive alterations in patients with mild autonomous cortisol secretion (MACS). We also sought to assess whether the anticipated changes in brain volume and cognitive functions of the patients with MACS differ from the changes in patients with overt Cushing’s Syndrome (CS). Methods: In this cross-sectional study, volumes of the cortex, hippo...

Background and aims: It is reported that intracellular adhesion molecule-1 (ICAM-1) is important in autoimmune thyroid diseases also it is an important point that ICAM-1 level is high in postoperative hypothyroid cases. In literature, it is said that the level of plasma soluble ICAM-1 can be used as a evidence immune system activation and inflammation, and also it can be used for the diagnosis of some inflammatory and autoimmune diseases. The aim of our was to compare the leve...

Introduction: We evaluated the characteristics of differentiated thyroid carcinoma in geriatric patients and factors that influenced long-term survival in this retrospective study design. Among 1188 patients with differentiated thyroid carcinoma who were treated at our institution over the past 7 years, 144 patients were identified who were age 65 years or older(age range:65–88 years) at the time of their initial diagnosis. This study conducted a retrospective analysis of...

Introduction: The term congenital adrenal hyperplasia (CAH) encompasses a group of autosomal recessive disorders, each of which involves a deficiency of an enzyme involved in the synthesis of cortisol, aldosterone, or both. Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases.Case report: Two female siblings were referred to endocrine clinic with the complain ...

Background: Our aim was to investigate levels of lipocalin-2 and its relationship with metabolic factors in women with polycystic ovary syndrome (PCOS).Materials/subjects and methods: In this cross-sectional study, two groups of women were studied: group 1 consisted of women with PCOS (n=30), and group 2 consisted of control women with normal ovulatory function (n=30). The circulating levels of lipocalin were measured.<p class="abstext"...

Introduction: Carbohydrate antigen 19-9 (CA 19-9) is a glycosphingolipid of the Lewis blood group that for years has been proposed as a useful marker for epithelial type gastrointestinal cancers. It is well known that moderately increased concentrations of CA 19-9 can be found in 15–36% of patients with benign conditions such as pancreatic, liver, biliary diseases and benign hydronephrosis. In current study, we aimed to investigate whether there was any tendency CA 19-9 e...

Objective: C-reactive protein (CRP) is a nontraditional risk factor that predicts cardiovascular disease but its relationship between diabetes and insulin resistance is not well documented. We evaluated the association of CRP levels and insulin resistance in a group of patients at high risk for diabetes.Materials and methods: In this study we evaluated 22 first degree relatives of type 2 diabetic patients with impaired glucose tolerance test (Group 1) an...

Aim: To identify the causes and predictors of mortality in acromegaly patients diagnosed, treated, and followed in the Pituitary Center of Istanbul University-Cerrahpasa over the last three decades using machine learning (ML) models.Methods: The study sample consisted of 607 consecutive patients diagnosed with acromegaly at Cerrahpasa Faculty of Medicine during the period 1990 – 2023. The main inclusion criteria were age > 18 years and a clear-c...

Objective: To determine the frequency of polycystic ovary syndrome (PCOS) in women with prediabetes compared to control women.Methods: Digital screening and tele-interviews remotely excluded 3218 out of 3465 consecutive women applied for routine check-up. In-person assessments were performed on 247 women, excluding 49. Final analyses included 198 premenopausal women without endocrine disorders (other than prediabetes and PCOS) or conditions affecting gon...