Endocrine Abstracts

The question on how cells, tissues and organisms are able to detect energy/nutrient availability has been the focus of research for many years. Data gleaned recently have identified different nutrient-sensing circuits implicated in the regulation of different homeostatic process. Furthermore, there has been a steady increase in our knowledge regarding the cellular and molecular mechanisms involved in nutrient detection and integration. In particular, this has allowed for a bet...

This prestigious prize is intended for established workers in the field of basic and clinical neuroendocrinology and is generously supported by Ipsen. This year’s recipient is Prof. Carlos Dieguez. The prize will be presented as part of the ECE 2015 opening ceremony where Prof. Dieguez will deliver his lecture. Prof. Dieguez will also deliver two other lectures at future ESE scientific meetings. Further information can be found at <a href="http://www.ese-hormones.org/priz...

Current indications for adjuvant Radioactive Iodine (RAI) in low- and intermediate-risk differentiated thyroid cancer (DTC) are controversial. At the same time, there is universal consensus for personalized DTC management according to individual patient needs, as there does not appear to be a ‘‘right’’ way to treat patients with DTC. According to the Martinique Principles 1, adjuvant RAI treatment has many goals, including: initial stagi...

Background: The epidemic of obesity, together with its associated health burden, continues to spread globally. It is estimated that approximately 2.1 billion adults worldwide are now classified as overweight or obese. Thus, there is an urgent need to develop more effective strategies for preventing and managing obesity. Most population strategies to reduce the rising prevalence of non-communicable diseases (NCDs) have used a ‘one size fits all’ public health recommen...

Introduction: Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of rare metabolic diseases, all characterized by end-organ resistance to the action of different hormones, primarily PTH. Main clinical characteristics are hypocalcemia and hyperphosphoremia associated with elevated parathyroid hormone (PTH) levels, frequently encompassing additional heterogeneous features, known as Albright’s hereditary osteodystrophy. A molecular cause can be identified in 80&...

Vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease. The vitamin D receptor (VDR) and the 1a-hydroxylase enzyme are present in critical cells implicated in the development of vascular disease. Vitamin D influences multiple mechanisms to decrease vascular inflammation: it suppresses the renin-angiotensin system, promotes endothelial nitric oxide release, decreases vascular in...

Purpose: To evaluate if patients with low- or intermediate-risk differentiated thyroid cancer (DTC) can be discharged to primary care.Material and Methods: The clinical records and evolution of 346 patients with DTC who had undergone surgery between 1995 and 2020 with a follow-up after a mean of 7.6 ± 6.1 years were retrospectively reviewed. All had a low or intermediate risk of recurrence as defined under the 2015 ATA risk stratification system and...

Introduction: Premature ovarian insufficiency is characterized by precocious depletion of ovarian follicles, associated with amenorrhea, hypoestrogenism and high gonadotropin levels. It afflicts 1% of the female population and in 5% cases it is due to X chromosome abnormalities.Case report: A 22 year old previously healthy female, presented to the Endocrinology Clinic due to amenorrhea. She had no family history of amenorrhea, her menarche was at age 11 ...

Introduction: Hypophosphatasia (HPP) is a rare genetic disease of very variable severity (from letal to mild). HPP results from APL gene mutations, which lead to a deficiency of tissue-nonspecifc alcaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP in the extracelular space. HPP causes mineralization disorders including soft bones (rickets, osteomalacia, fractures) and defects in...

Introduction: Dopamine agonists are the mainstay treatment for prolactinomas, but clinical characteristics that predict their effects on prolactin (PRL) suppression and tumour shrinkage are missing. Our study aimed to find measures in early follow-up of men harbouring macroprolactinomas, that will predict dynamics of PRL decrease and adenoma shrinkage.Methods: A single centre historical prospective study, including a consecutive group of 71 men with pitu...